N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Base Information

Chemical Name:N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine
CAS No.:1083302-71-9
Molecular Formula:C₃₇H₃₄F₂N₆O₃Si
Molecular Weight:676.798
Hs Code.:

N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Synonyms:N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Suppliers and Price of N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

There total 14 articles about N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1018978-53-4
6-fluoro-1-(5-nitro-4-thiocyanatopyrimidin-2-yl)-1H-benzo[d]imidazole

: 1083302-43-5
(1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

: 1083302-71-9
N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; at 20 ℃; for 16h;

Reference yield:

: 1055949-62-6,462105-66-4
(R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

: 1083302-71-9
N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; trifluoroacetic anhydride / dichloromethane / 16.33 h / 0 - 20 °C

2: potassium permanganate; magnesium sulfate / water; acetone / 17 h / 0 - 20 °C

3: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 0 - 40 °C

4: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

5: potassium carbonate / methanol; water / 72 h / 50 °C

6: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 16 h / 20 °C

With 1H-imidazole; potassium permanganate; formic acid; magnesium sulfate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; Noyori's catalyst; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1083302-30-0
(S)-7-fluoro-1-tetralol

: 1083302-71-9
N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2-(6-fluoro-1H-benzo[d]imidazol-1-yl)-5-nitropyrimidin-4-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1810.07 Torr

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 16.33 h / 0 - 20 °C

4.1: potassium permanganate; magnesium sulfate / water; acetone / 17 h / 0 - 20 °C

5.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 0 - 40 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

7.1: potassium carbonate / methanol; water / 72 h / 50 °C

8.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; dimethyl sulfoxide / 16 h / 20 °C

With 1H-imidazole; potassium permanganate; formic acid; hydrogen; magnesium sulfate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; Noyori's catalyst; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;