(S)-7-fluoro-1-tetralol

Base Information

Chemical Name:(S)-7-fluoro-1-tetralol
CAS No.:1083302-30-0
Molecular Formula:C₁₀H₁₁FO
Molecular Weight:166.195
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-fluoro-1-tetralol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-7-fluoro-1-tetralol

There total 1 articles about (S)-7-fluoro-1-tetralol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2840-44-0
7-fluoro-3,4-dihydronaphthalen-1(2H)-one

: 1083302-30-0
(S)-7-fluoro-1-tetralol

: 1313511-69-1
C₂₈H₂₅FOSi

: (R)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / ethanol / 20 °C / Inert atmosphere

2.1: (1-ethylpropyl)diisopropylamine; Levamisole / tetrahydrofuran / 0.5 h / -78 °C / Molecular sieve; Inert atmosphere; Resolution of racemate

2.2: 14 h / -78 °C / Inert atmosphere; Resolution of racemate

With sodium tetrahydroborate; (1-ethylpropyl)diisopropylamine; Levamisole; In tetrahydrofuran; ethanol;
DOI:10.1021/ol2012617

Reference yield:

: 1083302-30-0
(S)-7-fluoro-1-tetralol

: 1083302-43-5
(1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1810.07 Torr

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 16.33 h / 0 - 20 °C

4.1: potassium permanganate; magnesium sulfate / water; acetone / 17 h / 0 - 20 °C

5.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 0 - 40 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

7.1: potassium carbonate / methanol; water / 72 h / 50 °C

With 1H-imidazole; potassium permanganate; formic acid; hydrogen; magnesium sulfate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; Noyori's catalyst; palladium 10% on activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1083302-30-0
(S)-7-fluoro-1-tetralol

: 1083302-41-3
N-((1R,4R)-4-(tert-butyldiphenylsilyloxy)-7-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene

1.2: 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 1810.07 Torr

3.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 16.33 h / 0 - 20 °C

4.1: potassium permanganate; magnesium sulfate / water; acetone / 17 h / 0 - 20 °C

5.1: formic acid; triethylamine / Noyori's catalyst / N,N-dimethyl-formamide / 0 - 40 °C

6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With 1H-imidazole; potassium permanganate; formic acid; hydrogen; magnesium sulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic anhydride; Noyori's catalyst; palladium 10% on activated carbon; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene;