methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

Base Information

Chemical Name:methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate
CAS No.:913078-90-7
Molecular Formula:C₂₃H₂₂F₃NO₆S
Molecular Weight:497.492
Hs Code.:

Synonyms:methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

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Chemical Property of methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

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Technology Process of methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

There total 11 articles about methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 69815-95-8
5-methylfuran-2-sulfonyl chloride

: 913078-88-3
methyl 3-(4-{[2-amino-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

: 913078-90-7
methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

Guidance literature:: With pyridine; In dichloromethane; for 9h;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 534-22-5
2-methylfuran

: 913078-90-7
methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / acetonitrile / 23 h / 40 °C

2: 41 percent / oxalyl chloride / 1,2-dimethoxy-ethane; dimethylformamide / 3 h / 20 °C

3: 100 percent / pyridine / CH₂Cl₂ / 9 h

With pyridine; oxalyl dichloride; In 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2006.06.067

Reference yield:

: 907587-46-6
methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate

: 913078-90-7
methyl 3-(4-{[2-{[(5-methyl-2-furyl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}phenyl)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1: 85 percent / lithium borohydride / diethyl ether; methanol / Heating

2: 81 percent / dimethylsulfoxide; sulfur trioxide pyridine complex; diisopropylethylamine / ethyl acetate / 0.5 h

3: 90 percent / piperidine; pyridine / 0.5 h / 100 °C

4: 100 percent / potassium carbonate / dimethylformamide / 1.5 h / 65 °C

5: 91 percent / iron; acetic acid / H₂O / 0.5 h / 50 °C

6: 74 percent / sodium borohydride; nickel(II) chloride hexahydrate / ethanol; tetrahydrofuran / 1 h / 20 °C

7: 100 percent / pyridine / CH₂Cl₂ / 9 h

With piperidine; pyridine; sodium tetrahydroborate; lithium borohydride; sulfur trioxide pyridine complex; iron; potassium carbonate; acetic acid; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; nickel dichloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.06.067