methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

Base Information

Chemical Name:methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate
CAS No.:258532-43-3
Molecular Formula:C₂₉H₃₃NO₃S
Molecular Weight:475.652
Hs Code.:

Synonyms:methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

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Technology Process of methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

There total 7 articles about methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 258533-03-8
methyl (1-(2-hydroxyethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

: 558-13-4
carbon tetrabromide

: 74630-84-5
1,1-diphenylethane-1-thiol

: 258532-43-3
methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

Guidance literature:: With ammonium chloride; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: [1-(2-bromo-ethyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-6-yloxy]-acetic acid methyl ester

: 74630-84-5
1,1-diphenylethane-1-thiol

: 258532-43-3
methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 3h;
DOI:10.1016/j.bmc.2005.10.050

Reference yield:

: 163299-16-9
6-acetoxy-2-oxo-2,3,4,5-tetrahydro-1H-benzazepine

: 258532-43-3
methyl (1-(2-(1,1-diphenylethylthio)ethyl)-2,3,4,5-tetrahydro-1H-benzazepin-6-yloxy)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / K₂CO₃ / dimethylformamide / 20 °C

2: 81 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 °C

3: 67 percent / K₂CO₃ / dimethylformamide / 20 °C

4: carbon tetrabromide; triphenylphosphine / CH₂Cl₂ / 3.5 h / 0 °C

5: 532 mg / sodium hydride / dimethylformamide / 3 h / 0 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sodium hydride; potassium carbonate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.050