(S)-N-BOC-alpha-Ethylalanine, 98% ee, 98%

Base Information

• Chemical Name: (S)-N-BOC-alpha-Ethylalanine, 98% ee, 98%
• CAS No.: 151171-11-8
• Molecular Formula: C10H19NO4
• Molecular Weight: 217.265
• Mol file: 151171-11-8.mol

Synonyms:(S)-N-BOC-alpha-Ethylalanine, 98% ee, 98%;(S)-N-BOC-alpha-Ethylalanine, 98%, 98% ee;Boc-(S)-2-aMino-2-Methylbutanoic acid;(S)-N-BOC-alpha-Ethylalanine;Boc-α-Me-Gly(Ethyl)-OH;Boc-alpha-Et-D-Ala-OH

Chemical Property of (S)-N-BOC-alpha-Ethylalanine, 98% ee, 98%

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 341.845°C at 760 mmHg
• Flash Point: 160.542°C
• PSA: 75.63000
• Density: 1.083g/cm³
• LogP: 2.15530
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Boc-α-Me-Gly(Ethyl)-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-N-BOC-alpha-Ethylalanine, 98% ee, 98%

There total 4 articles about (S)-N-BOC-alpha-Ethylalanine, 98% ee, 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

L-isovaline (595-40-4,465-58-7) + di-tert-butyl dicarbonate (24424-99-5) → (S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid (151171-11-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; for 144h; Ambient temperature;

Reference yield:

tert-butyl (S)-[1-(hydroxymethyl)-1-methylpropyl]carbamate (252953-46-1) → (S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid (151171-11-8)

Guidance literature:

With jones reagent; In acetone; at 0 - 20 ℃; for 6h;

DOI:10.1021/jo990957o

Reference yield:

(S)-N-(tert-butoxycarbonyl)-4-vinyl-2,2,4-trimethyl-3-oxazolidine (252953-44-9) → (S)-2-((tert-butoxycarbonyl)amino)-2-methylbutanoic acid (151171-11-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / hydrogen / palladium on carbon / ethyl acetate / 12 h / 20 °C

2: 93 percent / water; Sc(OTf)3 / acetonitrile / 24 h / 25 °C

3: Jones reagent / acetone / 6 h / 0 - 20 °C

With jones reagent; water; hydrogen; scandium tris(trifluoromethanesulfonate); palladium on activated charcoal; In ethyl acetate; acetone; acetonitrile; 1: Catalytic hydrogenation / 2: Hydrolysis / 3: Oxidation;

DOI:10.1021/jo990957o

upstream raw materials:

L-isovaline

di-tert-butyl dicarbonate

tert-butyl (S)-[1-(hydroxymethyl)-1-methylpropyl]carbamate

(S)-N-(tert-butoxycarbonyl)-4-ethyl-2,2,4-trimethyloxazolidine

Downstream raw materials:

N-tert-butoxycarbonyl-L-isovaline benzyl ester

(2S)-2-amino-2-methylbutanoic acid hydrochloride

Boc-Gln-S-EtA-Hyp-Ala-Phol

Boc-Gln-S-EtA-Hyp-MeA-Phol