2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

Base Information

Chemical Name:2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol
CAS No.:415679-63-9
Molecular Formula:C₂₄H₂₁N₃O₂
Molecular Weight:383.45
Hs Code.:

Synonyms:2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

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Chemical Property of 2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

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Technology Process of 2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

There total 5 articles about 2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 415679-62-8
bromo(6-methoxypyridin-2-yl)(6-phenylpyridin-2-yl)pyridin-2-ylmethane

: 415679-63-9
2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

Guidance literature:: bromo(6-methoxypyridin-2-yl)(6-phenylpyridin-2-yl)pyridin-2-ylmethane; With n-butyllithium; In diethyl ether; hexane; at -90 ℃;

formaldehyd; In diethyl ether; hexane; at -90 - 20 ℃; for 14h;
DOI:10.1055/s-2001-18716

Reference yield:

: 100-70-9,1232006-36-8
2-Cyanopyridine

: 415679-63-9
2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / -78 - 20 °C

1.2: diethyl ether; hexane / -78 - 20 °C

1.3: 41 percent / aq. HCl / diethyl ether; hexane / 2 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / -75 °C

2.2: 63 percent / tetrahydrofuran; hexane / 0.25 h / -80 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 20 °C

3.2: 79 percent / SOBr₂ / tetrahydrofuran; hexane / 15 h / -70 - 20 °C

4.1: n-BuLi / diethyl ether; hexane / -90 °C

4.2: 79 percent / diethyl ether; hexane / 14 h / -90 - 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1055/s-2001-18716

Reference yield:

: 39774-26-0
2-bromo-6-phenylpyridine

: 415679-63-9
2-(6-methoxypyridin-2-yl)-2-(6-phenylpyridin-2-yl)-2-pyridin-2-ylethanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi / diethyl ether; hexane / -78 - 20 °C

1.2: diethyl ether; hexane / -78 - 20 °C

1.3: 41 percent / aq. HCl / diethyl ether; hexane / 2 h / Heating

2.1: n-BuLi / tetrahydrofuran; hexane / -75 °C

2.2: 63 percent / tetrahydrofuran; hexane / 0.25 h / -80 °C

3.1: n-BuLi / tetrahydrofuran; hexane / 0.17 h / 20 °C

3.2: 79 percent / SOBr₂ / tetrahydrofuran; hexane / 15 h / -70 - 20 °C

4.1: n-BuLi / diethyl ether; hexane / -90 °C

4.2: 79 percent / diethyl ether; hexane / 14 h / -90 - 20 °C

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1055/s-2001-18716