2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

Base Information

Chemical Name:2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate
CAS No.:898838-05-6
Molecular Formula:C₂₅H₂₅F₃N₂O₇S
Molecular Weight:554.544
Hs Code.:

Synonyms:2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

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Chemical Property of 2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

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Technology Process of 2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

There total 11 articles about 2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 898838-04-5
(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

: 358-23-6
trifluoromethylsulfonic anhydride

: 898838-05-6
2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/ol061002c

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 898838-05-6
2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 68 percent / anhydrous potassium carbonate / dimethylformamide / 5 - 20 °C

2.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

3.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

3.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

4.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

5.1: 55 percent / hydrochloric acid / CH₂Cl₂; ethanol / 4 h / 60 °C

6.1: 100 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; hydrogenchloride; tert.-butyl lithium; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; pentane; 2.1: Kumada cross-coupling;
DOI:10.1021/ol061002c

Reference yield:

: 162271-10-5
2-Bromo-3-(methoxymethoxy)pyridine

: 898838-05-6
2-isobutyl-4-(5-methoxy-4-(4-methoxybenzyloxy)-2-pyridinoyl)pyridin-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

2.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

2.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

3.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

4.1: 55 percent / hydrochloric acid / CH₂Cl₂; ethanol / 4 h / 60 °C

5.1: 100 percent / pyridine / CH₂Cl₂ / 3 h / 20 °C

With pyridine; hydrogenchloride; tert.-butyl lithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; pentane; 1.1: Kumada cross-coupling;
DOI:10.1021/ol061002c