(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Base Information

Chemical Name:(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone
CAS No.:898838-04-5
Molecular Formula:C₂₄H₂₆N₂O₅
Molecular Weight:422.481
Hs Code.:

Synonyms:(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

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Chemical Property of (3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

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Technology Process of (3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

There total 10 articles about (3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 898838-03-4
(2-isobutyl-3-(methoxymethoxy)pyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

: 898838-04-5
(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Guidance literature:: With hydrogenchloride; In ethanol; dichloromethane; at 60 ℃; for 4h;
DOI:10.1021/ol061002c

Reference yield:

: 6602-32-0
2-bromo-pyridin-3-ol

: 898838-04-5
(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: 68 percent / anhydrous potassium carbonate / dimethylformamide / 5 - 20 °C

2.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

3.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

3.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

4.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

5.1: 55 percent / hydrochloric acid / CH₂Cl₂; ethanol / 4 h / 60 °C

With hydrogenchloride; tert.-butyl lithium; potassium carbonate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; pentane; 2.1: Kumada cross-coupling;
DOI:10.1021/ol061002c

Reference yield:

: 162271-10-5
2-Bromo-3-(methoxymethoxy)pyridine

: 898838-04-5
(3-hydroxy-2-isobutylpyridin-4-yl)(5-methoxy-4-(4-methoxybenzyloxy)pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 59 percent / [1,3-bis(diphenylphosphino)propane]dichloronickel(II) / diethyl ether / 1 h / Heating

2.1: tert-butyllithium / diethyl ether; pentane / 0.75 h / -78 °C

2.2: 1.79 g / diethyl ether; pentane; tetrahydrofuran / 2.25 h / -78 - 20 °C

3.1: 0.77 g / o-iodoxybenzoic acid / dimethylsulfoxide / 2 h / 20 °C

4.1: 55 percent / hydrochloric acid / CH₂Cl₂; ethanol / 4 h / 60 °C

With hydrogenchloride; tert.-butyl lithium; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; [1,3-bis(diphenylphosphino)propane]dichloronickel(II); In diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; pentane; 1.1: Kumada cross-coupling;
DOI:10.1021/ol061002c