Technology Process of 6'-PNZ-2'-(N-phthalimido-3-amino-propyl)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin
There total 13 articles about 6'-PNZ-2'-(N-phthalimido-3-amino-propyl)-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-(N-phthaloyl)propionaldehyde; 6'-PNZ-3,3''-diBoc-1-(N-Boc-4-amino-2(S)-hydroxy-butyryl)-sisomicin;
In
N,N-dimethyl-formamide;
for 2h;
Molecular sieve;
With
sodium cyanoborohydride;
In
methanol; N,N-dimethyl-formamide;
With
water; sodium hydrogencarbonate; ammonium chloride;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium carbonate / 1,4-dioxane; water
2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / -40 °C
3: 4-methyl-morpholine / tetrahydrofuran / 18 h / 0 °C
4: sodium hydroxide; sodium dithionite; ethanol; water / 18 h / 70 °C
5: N-ethyl-N,N-diisopropylamine / methanol / 1 h
6: N,N-dimethyl-formamide / 2 h / Molecular sieve
With
4-methyl-morpholine; sodium hydroxide; sodium dithionite; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: nickel diacetate / methanol / 0 - 20 °C
2: zinc diacetate / methanol / 8 h / 0 °C
3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / -40 °C
4: 4-methyl-morpholine / tetrahydrofuran / 18 h / 0 °C
5: sodium hydroxide; sodium dithionite; ethanol; water / 18 h / 70 °C
6: N-ethyl-N,N-diisopropylamine / methanol / 1 h
7: N,N-dimethyl-formamide / 2 h / Molecular sieve
With
4-methyl-morpholine; sodium hydroxide; sodium dithionite; ethanol; zinc diacetate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; nickel diacetate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
