2436-29-5

Basic information

• Product Name: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE
• Synonyms: 3-(Phthalimid-1-yl)propanal;2H-Isoindole-2-propanal,1,3-dihydro-1,3-dioxo-;3-(1,3-Dioxoisoindolin-2-yl)propanal;.beta.-Phthalimidopropionaldehyde;2H-Isoindole-2-propanal, 1,3-dihydro-1,3-dioxo- (9CI);3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal;3-(1,3-dioxo-2-isoindolinyl)propanal;beta-Phthalimidopropionaldehyde
• CAS NO: 2436-29-5
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.19
• Mol File: 2436-29-5.mol
• Article Data: 56

Chemical Properties

• Melting Point: 136-141 ºC
• Boiling Point: 352.7 °C at 760 mmHg
• Flash Point: 165 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 3.77E-05mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: -2.24±0.20(Predicted)
• CAS DataBase Reference: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE(2436-29-5)
• EPA Substance Registry System: 3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONALDEHYDE(2436-29-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• Hazardous Substances Data: 2436-29-5(Hazardous Substances Data)

Usage

General Description

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionaldehyde is a chemical compound with the molecular formula C11H9NO3. It is an aromatic aldehyde with a substituted isoindoline core structure, featuring a propionaldehyde side chain. This chemical may have applications in organic synthesis and pharmaceutical research as a building block for the creation of more complex molecules. Its structure suggests potential reactivity in organic reactions, and it may be used as a precursor in the synthesis of various compounds. Additionally, it may have biological activity, although specific information regarding its potential uses or effects in biological systems is not readily available.

InChI:InChI=1/C11H9NO3/c13-7-3-6-12-10(14)8-4-1-2-5-9(8)11(12)15/h1-2,4-5,7H,3,6H2

Upstream product

• 883-44-3 N-(3-hydroxypropyl)phthalimide 
• 7223-50-9 N-propargylphthalimide 
• 1074-82-4 potassium phtalimide 
• 136918-14-4 phthalimide 
• 107-02-8 acrolein 
• 64-17-5 ethanol 
• 141-52-6 sodium ethanolate 
• 18742-02-4 2-bromo-2-(2-ethyl)dioxolane 
• 3339-73-9 3-phthalimidopropanoic acid 
• 201230-82-2 carbon monoxide 
• 3485-84-5 N-vinylphthalimide 
• 2065-67-0 tetraphenylphosphonium iodide 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 24697-70-9 N-(4-hydroxybutyl)phthalimide 

Downstream Products

• 88883-77-6 N-[2-(1H-imidazol-2-yl)-ethyl]-phthalimide 
• 130712-29-7 trans-4,5-dihydro-5-(2-phthalimidoethyl)oxazole-4-carboxamide 
• 130712-30-0 N-(4-Amino-4-carbamoyl-3-hydroxy-butyl)-phthalamic acid 
• 130677-02-0 benzyl 3-hydroxy-2-(2-oxoazetidin-1-yl)-5-phthalimidovalerate 
• 118972-83-1 2-(6-Benzyloxy-3-hydroxy-hex-4-ynyl)-isoindole-1,3-dione 
• 150693-72-4 (Z)-2-Benzoylamino-5-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-pent-2-enoic acid methyl ester 
• 125416-31-1 E-10-dicyclohexylsulfamoyl-D-isobornyl 4-hydroxy-5-phthalimidopent-2-enoate 
• 74523-51-6 1,3-Diphenyl-6-phthalimidohexan-1,4-dion 
• 88883-79-8 2-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-ethyl]-isoindole-1,3-dione 
• 74510-01-3 1-Phenyl-6-phthalimido-1,4-hexandion 
• 100840-56-0 ethyl 4<(3-phthalimidopropyl)amino>benzoate 
• 307494-00-4 (E)-5-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-pent-2-enoic acid benzyl ester 
• 222022-30-2 2-{2-[2-(toluene-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl]-ethyl}-isoindole-1,3-dione 
• 388629-96-7 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-(2-phthalimidoethyl)isoquinoline 

Relevant articles and documents

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Divergent Stereocontrolled Synthesis of the Enantiopure Tetracyclic Cores of Asparagamine A and Stemofoline via an Intramolecular 2-Propylidine-1,3-(bis)silane Bicyclization

A concise and highly diastereoselective synthesis of the polyfused tetracyclic cores of the Stemona alkaloids asparagamine A and stemofoline that relies on a 2-propylidine-1,3-(bis)silane bicyclization onto a enantiodefined pyrrolidine 2,5-di(cation) equivalent derived from l-malic acid is reported. A crucial feature of this divergent synthetic approach involves the solvolysis of a transient and highly labile tertiary-propargylic hydroxylactam trifluoroacetate in the strongly ionizing medium 5 M LiClO4/Et2O. The acyliminium ion generated in this manner undergoes stereospecific interception by the aforementioned (bis)silane nucleophile.

Robust synthesis and crystal-structure analysis of 7-cyano-7-deazaguanine (PreQ0 base) and 7-(aminomethyl)-7-deazaguanine (PreQ1 base)

We describe robust and efficient synthetic methods for the synthesis of the preQ0 and preQ1 bases, which are the biosynthetic precursors of the hypermodified RNA nucleoside queuosine. The X-ray crystal-structure analysis of preQ1 is also described.

Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis

A cross-selective aza-pinacol coupling of aldehydes and imines has been developed to afford valuable β-amino alcohols. This strategy enables chemoselective conversion of aliphatic aldehydes to ketyl radicals, in the presence of more easily reduced imines and other functional groups. Upon carbonyl-specific activation by AcI, a photoinitiated Mn catalyst selectively reduces the resulting α-oxy iodide by an atom transfer mechanism. The ensuing ketyl radical selectively couples to imines, precluding homodimerization by a classical reductive approach. In this first example of reductive, ketyl coupling by atom transfer catalysis, Zn serves as a terminal reductant to facilitate Mn catalyst turnover. This new strategy also enables ketyl radical couplings to alkenes, alkynes, aldehydes, propellanes, and chiral imines.

Synthesis process of spermidine and intermediate thereof

The invention provides a synthesis process of spermidine (I) which takes 3 -t-butyloxycarbonyl V (N -) and -1-t-butyloxycarbonyl 4 - IV butanediamine (N -) as a raw material to obtain the spermidine trihydrochloride (-4 - II III) by reductive amination reaction, and provides a novel method for chemical synthesis of spermidine by liberation of the protecting group from the intermediate I (3 -) to obtain the spermidine (III) II.