4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

Base Information

Chemical Name:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide
CAS No.:1093752-27-2
Molecular Formula:C₃₄H₂₆F₃N₅O₅
Molecular Weight:641.606
Hs Code.:

Synonyms:4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

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Chemical Property of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

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Technology Process of 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

There total 15 articles about 4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1093752-26-1
N-{[3-(5-chloropyridin-2-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl}-4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)benzamide

: 175676-65-0
2-trifluoromethoxyphenylboronic acid

: 1093752-27-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

Guidance literature:: With potassium carbonate; palladium di-tert-butylphosphinoferrocene; In tetrahydrofuran; at 150 ℃; for 0.25h; Microwave irradiation;

Reference yield:

: 1093395-66-4
4-(5-cyano-7-isopropyl-benzooxazol-2-yl)-benzoic acid

: 1093752-27-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With oxalyl dichloride; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; 3: Suzuki cross-coupling;
DOI:10.1016/j.bmcl.2011.02.049

Reference yield:

: 1093752-23-8
5-(chloromethyl)-3-(5-chloropyridin-2-yl)-1,3-oxazolidin-2-one

: 1093752-27-2
4-(5-cyano-7-isopropyl-1,3-benzoxazol-2-yl)-N-[(2-oxo-3-{5-[2-(trifluoromethoxy)phenyl]pyridin-2-yl}-1,3-oxazolidin-5-yl)methyl]benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium azide / N,N-dimethyl-formamide

2: triphenylphosphine / tetrahydrofuran; water

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

4: dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate

With sodium azide; dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; 4: Suzuki cross-coupling;
DOI:10.1016/j.bmcl.2011.02.049