5,6-DIMETHYL-PYRIMIDIN-4-OL

Base Information

• Chemical Name: 5,6-DIMETHYL-PYRIMIDIN-4-OL
• CAS No.: 34916-78-4
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.142
• Hs Code.: 2933599090
• Mol file: 34916-78-4.mol

Synonyms:4(1H)-Pyrimidinone,5,6-dimethyl- (9CI); 4-Pyrimidinol, 5,6-dimethyl- (7CI);4-Hydroxy-5,6-dimethylpyrimidine; 5,6-Dimethyl-4-hydroxypyrimidine

Chemical Property of 5,6-DIMETHYL-PYRIMIDIN-4-OL

Chemical Property:

• Vapor Pressure: 0.0104mmHg at 25°C
• Melting Point: 202-204 °C
• Refractive Index: 1.548
• Boiling Point: 255°Cat760mmHg
• PKA: 9.62±0.50(Predicted)
• Flash Point: 108°C
• PSA: 46.01000
• Density: 1.161g/cm³
• LogP: 0.79900
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5,6-Dimethylpyrimidin-4(3H)-one ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 5,6-Dimethylpyrimidin-4(3H)-one is used in preparation of pyrimidine derivatives for treatment of α1-antitrypsin deficiency.

Technology Process of 5,6-DIMETHYL-PYRIMIDIN-4-OL

There total 9 articles about 5,6-DIMETHYL-PYRIMIDIN-4-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylpropanoic acid ethyl ester (609-14-3) + formamidine hydrochloride (6313-33-3) → 4-Hydroxy-5,6-dimethyl-pyrimidin (34916-78-4)

Guidance literature:

With sulfuric acid; sodium methylate; In methanol; diethyl ether; ethanol; water;

Reference yield:

5,6-dimethyl-2-thiouracil (28456-54-4) → 5,6-dimethyl-3H-pyrimidin-4-one (34916-78-4)

Guidance literature:

With dihydrogen peroxide; at 70 - 90 ℃;

DOI:10.1021/ja01282a028

Reference yield:

methyl 3-amino-2-methylcrotonate + butan-1-ol (71-36-3) → 4-Hydroxy-5,6-dimethyl-pyrimidin (34916-78-4)

Guidance literature:

With sodium methylate; formamide;

upstream raw materials:

5,6-dimethyl-2-thiouracil

N-(3,4-dimethyl-isoxazol-5-yl)-formamide

2,4-dichloro-5,6-dimethylpyrimidine

2-acetylpropanoic acid ethyl ester

Downstream raw materials:

4-chloro-5,6-dimethylpyrimidine