(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

Base Information

Chemical Name:(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate
CAS No.:1071474-99-1
Molecular Formula:C₂₁H₃₁NO₇
Molecular Weight:409.48
Hs Code.:

Synonyms:(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

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Chemical Property of (S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

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Technology Process of (S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

There total 1 articles about (S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4326-36-7
(S)-N-(tert-butoxycarbonyl)tyrosine methyl ester

: 23737-51-1,7305-59-1
solketal tosylate

: 1071474-99-1
(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

Guidance literature:: With tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; In N,N-dimethyl-formamide; at 70 - 75 ℃; for 15h;

Reference yield: 100.0%

: 1071474-99-1
(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

: 1071475-00-7
(S)-methyl 2-amino-3-(4-(2,3-dihydroxypropoxy)phenyl)propanoate hydrochloride

Guidance literature:: (S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

With water; In 1,4-dioxane; methanol; at 20 ℃; for 2h;

Reference yield:

: 1071474-99-1
(S)-methyl-2-(tert-butoxycarbonylamino)-3-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)propanoate

: 1071475-01-8
(S)-methyl-2-((S)-2-azido-3-methylbutanamido)-3-(4-(2,3-dihydroxypropoxy)phenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

1.2: 2 h / 20 °C

2.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / tetrahydrofuran; N,N-dimethyl-formamide / 15 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;