1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

Base Information

• Chemical Name: 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea
• CAS No.: 59311-69-2
• Molecular Formula: C₁₃H₁₄N₂S₂
• Molecular Weight: 262.4
• Mol file: 59311-69-2.mol

Synonyms:1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

Chemical Property of 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea

There total 3 articles about 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[2-(2-thyenyl)ethyl]amine (30433-91-1) + phenyl isothiocyanate (103-72-0) → 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea (59311-69-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ol006191s

Reference yield:

2-cyanomethylthiophene (20893-30-5) → 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea (59311-69-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium alanate; diethyl ether

With lithium aluminium tetrahydride; diethyl ether;

DOI:10.1021/jo01147a014

Reference yield:

3-thiophen-2-yl-2-thioxo-propionic acid (89677-36-1) → 1-phenyl-3-(2-(thiophen-2-yl)ethyl)thiourea (59311-69-2)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol; hydroxylamine

2: acetic acid anhydride

3: lithium alanate; diethyl ether

With lithium aluminium tetrahydride; diethyl ether; ethanol; hydroxylamine; acetic anhydride;

DOI:10.1021/jo01147a014

upstream raw materials:

[2-(2-thyenyl)ethyl]amine

phenyl isothiocyanate

2-cyanomethylthiophene

3-thiophen-2-yl-2-thioxo-propionic acid

Refernces

• 1、 Yuan, Wen-Kui,Liu, Yan Fang,Lan, Zhenggang,Wen, Li-Rong,Li, Ming. "Nickle Catalysis Enables Access to Thiazolidines from Thioureas via Oxidative Double Isocyanide Insertion Reactions". supporting information. p. 7158 - 7162. Retrieved 2018/11/25.