methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate

Base Information

• Chemical Name: methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate
• CAS No.: 1538605-85-4
• Molecular Formula: C₁₉H₁₈F₄N₂O₂
• Molecular Weight: 382.358
• Mol file: 1538605-85-4.mol

Synonyms:methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate

Chemical Property of methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate

There total 1 articles about methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(3-Trifluoromethylphenyl)piperazine (15532-75-9) + methyl 4-bromo-2-fluorobenzoate (179232-29-2) → methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate (1538605-85-4)

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; at 50 ℃; for 48h;

DOI:10.1021/ml500010m

Reference yield:

methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate (1538605-85-4) → 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoic acid (1538605-86-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 70 ℃; for 2h;

DOI:10.1021/ml500010m

Reference yield:

methyl 2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoate (1538605-85-4) → (R)-N-(3-(1H-indol-3-yl)-1-oxo-1-(pyridin-4-ylamino)propan-2-yl)-2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzamide trifluoroacetate

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / methanol; tetrahydrofuran / 2 h / 70 °C

2.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine / dichloromethane / 0.25 h / 20 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1021/ml500010m

upstream raw materials:

1-(3-Trifluoromethylphenyl)piperazine

methyl 4-bromo-2-fluorobenzoate

Downstream raw materials:

2-fluoro-4-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)benzoic acid