(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

Base Information

Chemical Name:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile
CAS No.:1338326-81-0
Molecular Formula:C₂₁H₁₆ClN₅O₂
Molecular Weight:405.843
Hs Code.:

Synonyms:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

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Chemical Property of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

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Technology Process of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

There total 7 articles about (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.6%

: 1338327-46-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

: 3900-89-8
2-Chlorobenzeneboronic acid

: 1338326-81-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; water; at 110 ℃; for 0.666667h; Microwave irradiation; Sealed tube; Inert atmosphere;

Reference yield:

: 1338327-47-1
(R)-5-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-hydroxybenzonitrile

: 1338326-81-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

2: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.67 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With potassium phosphate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; 2: Suzuki Coupling;

Reference yield:

: 1338327-48-2
(R)-5-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-methoxybenzonitrile

: 1338326-81-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2'-chlorobiphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium thioethylate / N,N-dimethyl-formamide / 2 h / 140 °C

2: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

3: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.67 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With potassium phosphate; potassium carbonate; sodium thioethylate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3: Suzuki Coupling;