(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

Base Information

Chemical Name:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate
CAS No.:1338327-46-0
Molecular Formula:C₁₆H₁₂F₃N₅O₅S
Molecular Weight:443.363
Hs Code.:

Synonyms:(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

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Chemical Property of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

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Technology Process of (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

There total 6 articles about (R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1338327-47-1
(R)-5-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-hydroxybenzonitrile

: 1338327-46-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 72h;

Reference yield:

: 1338327-48-2
(R)-5-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-methoxybenzonitrile

: 1338327-46-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium thioethylate / N,N-dimethyl-formamide / 2 h / 140 °C

2: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

With potassium carbonate; sodium thioethylate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1338327-49-3
(R)-5-(4-chloro-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-methoxybenzonitrile

: 1338327-46-0
(R)-4-(4-amino-8-methyl-5-oxo-7,8-dihydropyrimido[5,4-f] [1,4]oxazepin-6(5H)-yl)-2-cyanophenyl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / 1,4-dioxane / 24 h / 55 °C

2: sodium thioethylate / N,N-dimethyl-formamide / 2 h / 140 °C

3: potassium carbonate / tetrahydrofuran / 72 h / 20 °C

With ammonia; potassium carbonate; sodium thioethylate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;