12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

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Chemical Name:12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine
CAS No.:876048-25-8
Molecular Formula:C₂₁H₁₆ClN₃O₂S₂
Molecular Weight:441.962
Hs Code.:

Synonyms:12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

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Chemical Property of 12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

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Technology Process of 12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

There total 5 articles about 12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 876048-21-4
5-(4-methylphenylsulphonyl)-6,7,11,12-tetrahydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepin-12-one

: 876048-25-8
12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

Guidance literature:: With trichlorophosphate; at 100 ℃; for 3h;

Reference yield: 20.0%

: 876048-17-8
2-amino-6-(4-methylphenylsulphonyl)-5,6-dihydro-4H-benzo[b]thieno[3,2-d]azepin-1-yl cyanide

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 876048-25-8
12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

: N'-[1-cyano-6-(toluene-4-sulfonyl)-5,6-dihydro-4H-3-thia-6-aza-benzo[e]azulen-2-yl]-N,N-dimethyl-formamidine

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.5h;

2-amino-6-(4-methylphenylsulphonyl)-5,6-dihydro-4H-benzo[b]thieno[3,2-d]azepin-1-yl cyanide; at 80 ℃; for 24h;

Reference yield:

: 876048-15-6
2-[1-(4-methylphenylsulphonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yliden] malononitrile

: 876048-25-8
12-chloro-5-(4-methylphenylsulphonyl)-6,7-dihydro-5H-benzo[b]pyrimido[5',4':4,5]thieno[3,2-d]azepine

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / sulfur; morpholine / ethanol / Heating

2: 85 percent / sodium acetate / 4 h / Heating

3: 78 percent / phosphoryl chloride / 3 h / 100 °C

With morpholine; sodium acetate; sulfur; trichlorophosphate; In ethanol;