(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

Base Information

Chemical Name:(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate
CAS No.:960524-25-8
Molecular Formula:C₄H₆O₄*C₂₄H₂₆F₆N₂O₂
Molecular Weight:606.562
Hs Code.:

Synonyms:(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

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Chemical Property of (R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

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Technology Process of (R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

There total 2 articles about (R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 960524-24-7
(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide

: 110-15-6
succinic acid

: 960524-25-8
(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

Guidance literature:: In ethyl acetate; Product distribution / selectivity; Heating / reflux; Ultrasonic irradiation;

Reference yield: 67.0%

: 110-15-6
succinic acid

: 960524-25-8
(R)-2-(methyloxy)-N-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]-4,6-bis(trifluoromethyl)benzamide monosuccinate

Guidance literature:: (R)-[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine R-(-)-α-methoxyphenylacetic acid salt; With sodium hydroxide; In dichloromethane; water; for 0.25h;

2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; acetonitrile; at 20 ℃; for 2.5h;

succinic acid; In ethyl acetate; at 70 ℃; for 0.666667h; Product distribution / selectivity;