dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

Base Information

Chemical Name:dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate
CAS No.:1205532-30-4
Molecular Formula:C₁₆H₁₆O₄
Molecular Weight:272.301
Hs Code.:

Synonyms:dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

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Chemical Property of dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

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Technology Process of dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

There total 1 articles about dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1205532-28-0
1-(3,5-dibromopent-1-ynyl)benzene

: 108-59-8
malonic acid dimethyl ester

: 1205532-30-4
dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

Guidance literature:: 1-(3,5-dibromopent-1-ynyl)benzene; malonic acid dimethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 2.08333h; Inert atmosphere;

In tetrahydrofuran; mineral oil; for 6h; Inert atmosphere; Reflux;
DOI:10.1039/b917332c

Reference yield: 95.0%

: 98-01-1
furfural

: 15226-74-1,61091-28-9,61117-58-6
dicobalt octacarbonyl

: 1205532-30-4
dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

: [Co₂(CO)6(C₆H₅CCCHCH₂CH₂C(COOCH₃)2CH(C₄H₃O)O)]

Guidance literature:: With molecular sieves; scandium tris(trifluoromethanesulfonate); In dichloromethane; substituted cyclobutane dissolved in CH2Cl2, activated molecular sieves added, dicobalt octacarbonyl added, stirred at room temp. under nitrogenatmosphere for 1.5 h, aldehyde added followed by scandium triflate, sti rred at room temp. for 10 min; filtered through pad of celite and silica, solvent evapd. in vac., purified by flash chromatography on silica gel (5% ethyl acetate - petrol), detd. by NOE expt., XRD;
DOI:10.1039/b917332c

Reference yield: 92.0%

: 15226-74-1,61091-28-9,61117-58-6
dicobalt octacarbonyl

: 1205532-30-4
dimethyl 2-(2-phenylethynyl)cyclobutane-1,1-dicarboxylate

: 120-14-9
3,4-dimethoxy-benzaldehyde

: [Co₂(CO)6(C₆H₅CCCHCH₂CH₂C(COOCH₃)2CH(C₆H₃(OCH₃)2)O)]

Guidance literature:: With molecular sieves; scandium tris(trifluoromethanesulfonate); In dichloromethane; substituted cyclobutane dissolved in CH2Cl2, activated molecular sieves added, dicobalt octacarbonyl added, stirred at room temp. under nitrogenatmosphere for 1.5 h, aldehyde added followed by scandium triflate, sti rred at room temp. for 10 min; filtered through pad of celite and silica, solvent evapd. in vac., purified by flash chromatography on silica gel (5% ethyl acetate - petrol), detd. by NOE expt.;
DOI:10.1039/b917332c