7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

Base Information

Chemical Name:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide
CAS No.:1392841-62-1
Molecular Formula:C₁₉H₁₉N₃O₃
Molecular Weight:337.378
Hs Code.:

Synonyms:7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

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Technology Process of 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

There total 5 articles about 7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-10-8,42939-71-9
propylamine

: 1392839-22-3
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid methyl ester

: 1392841-62-1
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

Guidance literature:: In ethanol; at 80 ℃; for 4h; Sealed tube;

Reference yield:

: 174740-67-1
dimethyl <2-(ethoxycarbonyl)ethylidene>malonate

: 1392841-62-1
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 80 °C

2.1: ethanol / 5 h / Reflux

3.1: pyridine; lithium iodide / 1 h / Reflux

4.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

4.2: 16 h / 20 °C

4.3: 16 h / 20 °C

5.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: sodium methylate / methanol

6.2: pH 4

7.1: ethanol / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 174740-68-2
5-dimethylamino-3-ethoxycarbonyl-2-methoxycarbonyl-penta-2,4-dienoic acid methyl ester

: 1392841-62-1
7-benzyl-4-hydroxy-8-oxo-7,8-dihydro-[2,7]naphthyridine-3-carboxylic acid propylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 5 h / Reflux

2.1: pyridine; lithium iodide / 1 h / Reflux

3.1: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.5 h

3.2: 16 h / 20 °C

3.3: 16 h / 20 °C

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol

5.2: pH 4

6.1: ethanol / 4 h / 80 °C / Sealed tube

With pyridine; oxalyl dichloride; sodium methylate; potassium carbonate; sodium iodide; lithium iodide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;