N-phenylcyclopropanecarboxamide

Base Information

• Chemical Name: N-phenylcyclopropanecarboxamide
• CAS No.: 2759-52-6
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.203
• Mol file: 2759-52-6.mol

Synonyms:N-phenylcyclopropanecarboxamide

Chemical Property of N-phenylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-phenylcyclopropanecarboxamide

There total 29 articles about N-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

cyclopropanecarboxylic acid chloride (4023-34-1) + aniline (62-53-3) → N-phenylcyclopropanecarboxamide (2759-52-6)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1021/jo0516988

Reference yield: 96.0%

N-tert-butyl-N'-phenyl-S-phenylisothiourea + cyclopropanecarboxylic acid (1759-53-1) → N-phenylcyclopropanecarboxamide (2759-52-6)

Guidance literature:

With iron(III)-acetylacetonate; In isopropyl alcohol; at 83 ℃; for 24h; Microwave irradiation;

DOI:10.1021/acs.orglett.6b02247

Reference yield: 96.0%

aniline (62-53-3) + Cyclopropanecarboxaldehyde (1489-69-6) → N-phenylcyclopropanecarboxamide (2759-52-6)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; 2,2,2-Trifluoroacetophenone; 1,3-bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene; In 1,4-dioxane; at 30 ℃; for 8h; Inert atmosphere; Glovebox;

DOI:10.1002/anie.201410322

upstream raw materials:

cyclopropanecarboxylic acid chloride

aniline

cyclopropanecarboxylic acid

(1S,2R)-2-Phenylsulfanyl-cyclopropanecarboxylic acid phenylamide

Downstream raw materials:

N-(4-bromophenyl)cyclopropanecarboxylic amide

1-phenylpyrrolidin-2-one

C₁₀H₁₀ClNO₃S

cyclopropanecarboxylic acid (4-nitrophenyl)amide