(5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE)

Base Information

Chemical Name:(5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE)
CAS No.:252337-59-0
Molecular Formula:C₄₁H₄₅F₃N₄O₉
Molecular Weight:794.825
Hs Code.:
Mol file:252337-59-0.mol

Synonyms:(5’-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2’-DEOXYURIDINE)

Suppliers and Price of (5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5''-O-(Dimethoxytrityl)-5-[N-(6-(trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2''-deoxyuridine
100mg
$ 360.00

TRC
5''-O-(Dimethoxytrityl)-5-[N-(6-(trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2''-deoxyuridine
50mg
$ 220.00

Medical Isotopes, Inc.
5?-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acryamido]-2?-deoxyuridine
50 mg
$ 390.00

Biosynth Carbosynth
5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine
1 g
$ 750.00

Biosynth Carbosynth
5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine
500 mg
$ 400.00

Biosynth Carbosynth
5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine
100 mg
$ 95.00

Biosynth Carbosynth
5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine
50 mg
$ 65.00

Biosynth Carbosynth
5'-O-DMT-5-[N-(6-(trifluoroacetamido)hexyl)-3-E-acrylamido]-2'-deoxyuridine
250 mg
$ 212.50

AK Scientific
(E)-3-[1-[(2R,4S,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]-N-[6-[(2,2,2-trifluoroacetyl)amino]hexyl]prop-2-enamide
100mg
$ 178.00

Total 13 raw suppliers

Chemical Property of (5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE)

Chemical Property:

PKA:8.73±0.10(Predicted)
PSA：170.21000
Density:1.315±0.06 g/cm3(Predicted)
LogP:5.36100

Purity/Quality:

98%,99%, ^*data from raw suppliers

5''-O-(Dimethoxytrityl)-5-[N-(6-(trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2''-deoxyuridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 5''-O-(Dimethoxytrityl)-5-[N-(6-(trifluoroacetamido)hexyl)-3-(E)-acrylamido]-2''-deoxyuridine can be used in rapid and efficient DNA strand cross-?linking by click chemistry.

Technology Process of (5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE)

There total 2 articles about (5'-O-(DIMETHOXYTRITYL)-5-[N-(6-(TRIFLUOROACETAMIDO)HEXYL)-3-(E)-ACRYLAMIDO]-2'-DEOXYURIDINE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 124022-79-3
N-acryloyl-N'-trifluoroacetyl-1,6-diaminohexane

: 252337-59-0
C₄₁H₄₅F₃N₄O₉

Guidance literature:: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine; With (1,3,5-triaza-7-phosphaadamantan-1-ium-1-yl)butane-1-sulfonate; palladium diacetate; triethylamine; In acetonitrile; for 0.0833333h; Inert atmosphere;

N-acryloyl-N'-trifluoroacetyl-1,6-diaminohexane; In acetonitrile; at 80 ℃; for 3h; Solvent; Catalytic behavior; Inert atmosphere;
DOI:10.1055/s-0040-1707260

Reference yield: 64.0%

: 104375-88-4
2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine

: 124022-79-3
N-acryloyl-N'-trifluoroacetyl-1,6-diaminohexane

: 252337-59-0
(E)-3-[1-(5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl]-N-[6-(2,2,2-trifluoroacetamido)hexyl]acrylamide

Guidance literature:: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-5-iodouridine; With t r i s ( 4 , 4 ’-methoxydibenzylideneacetone)dipalladium(0); tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 80 ℃; for 0.0833333h;

N-acryloyl-N'-trifluoroacetyl-1,6-diaminohexane; With triethylamine; In N,N-dimethyl-formamide; at 80 ℃; for 3h; Reagent/catalyst; Solvent; Temperature;
DOI:10.1055/s-0034-1379962

Reference yield:

: 252337-59-0
(E)-3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-(6-(2,2,2-trifluoroacetamido)hexyl)acrylamide

: C₅₈H₇₃N₅O₁₈

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide; potassium carbonate / methanol / 42 h / 20 °C

2: triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With ammonium hydroxide; potassium carbonate; benzotriazol-1-ol; triethylamine; In methanol; N,N-dimethyl-formamide;