2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

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Chemical Name:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride
CAS No.:78609-72-0
Molecular Formula:C₃₀H₄₀Cl₂N₂O₃*ClH
Molecular Weight:584.026
Hs Code.:

Synonyms:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

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Chemical Property of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

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Technology Process of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

There total 4 articles about 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 139512-47-3
2-Amino-3-methyl-butyric acid benzhydryl ester

: 78431-95-5
{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid; hydrochloride

: 78609-72-0
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

Guidance literature:: With dicyclohexyl-carbodiimide;
DOI:10.1007/BF00962271

Reference yield:

: 78431-89-7
{4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester

: 78609-72-0
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

2: 80 percent / aq. HCl / 1.5 h / Heating

3: 70 percent / 1,3-dicyclohexylcarbodiimide

With hydrogenchloride; thionyl chloride; dicyclohexyl-carbodiimide; In chloroform;
DOI:10.1007/BF00962271

Reference yield:

: 76308-15-1
cis-4-aminocyclohexylacetic acid ethyl ester

: 78609-72-0
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-methyl-butyric acid benzhydryl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂O

2: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

3: 80 percent / aq. HCl / 1.5 h / Heating

4: 70 percent / 1,3-dicyclohexylcarbodiimide

With hydrogenchloride; thionyl chloride; dicyclohexyl-carbodiimide; In chloroform; water;
DOI:10.1007/BF00962271