2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

Base Information

Chemical Name:2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester
CAS No.:94271-73-5
Molecular Formula:C₂₃H₂₂N₄O₈
Molecular Weight:482.45
Hs Code.:

Synonyms:2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

There total 5 articles about 2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 94271-74-6
4-[1-(2,4-Dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

: 94271-73-5
2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

Guidance literature:: With 4-toluenesulfonyl azide; triethylamine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 91921-98-1
[1-(2,4-dimethoxy-benzyl)-4-oxo-2-azetidinyl]-acetic acid

: 94271-73-5
2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1,1'-carbonyldi-imidazole, 2.) 0.5M HCl / 1.) THF, room temp., 2.5 h., 2.) CH₂Cl₂

2: 88 percent / triethylamine, toluene-p-sulphonyl azide / acetonitrile / 3 h / 20 °C

With hydrogenchloride; 4-toluenesulfonyl azide; triethylamine; 1,1'-carbonyldiimidazole; In acetonitrile;

Reference yield:

: 91921-97-0
(4RS)-4-diazoacetyl-1-(2,4-dimethoxybenzyl)azetidin-2-one

: 94271-73-5
2-Diazo-4-[1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-3-oxo-butyric acid 4-nitro-benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) 10percent aqueous NaOH / 1.) THF-water, irradiation, 4 h., 2.) water

2: 1.) 1,1'-carbonyldi-imidazole, 2.) 0.5M HCl / 1.) THF, room temp., 2.5 h., 2.) CH₂Cl₂

3: 88 percent / triethylamine, toluene-p-sulphonyl azide / acetonitrile / 3 h / 20 °C

With hydrogenchloride; sodium hydroxide; 4-toluenesulfonyl azide; triethylamine; 1,1'-carbonyldiimidazole; In acetonitrile;