[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester

Base Information

• Chemical Name: [2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester
• CAS No.: 668477-08-5
• Molecular Formula: C₁₇H₂₁NO₂S
• Molecular Weight: 303.425
• Mol file: 668477-08-5.mol

Synonyms:[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester

Chemical Property of [2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester

There total 1 articles about [2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

4-t-butyl phenyl thioamide (57774-77-3) + methyl 4-bromo-3-oxopentanoate (105983-77-5) + trimethyl orthoformate (149-73-5) → [2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester (668477-08-5)

Guidance literature:

4-t-butyl phenyl thioamide; methyl 4-bromo-3-oxopentanoate; In acetone; for 1h; Heating / reflux;

trimethyl orthoformate; With toluene-4-sulfonic acid; In methanol; for 2h; Heating / reflux;

Reference yield: 97.0%

[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester (668477-08-5) → 2-[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-ethanol

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

Reference yield:

[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-acetic acid methyl ester (668477-08-5) → methanesulfonic acid 2-[2-(4-tert-butyl-phenyl)-5-methyl-thiazol-4-yl]-ethyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C

2: pyridine / 0 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;

upstream raw materials:

4-t-butyl phenyl thioamide

methyl 4-bromo-3-oxopentanoate

trimethyl orthoformate