Technology Process of 3-fluoro-5-methoxy-4-methylaniline
There total 3 articles about 3-fluoro-5-methoxy-4-methylaniline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
20% palladium hydroxide-activated charcoal;
In
methanol;
under 2327.23 Torr;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N',N'',N'''-pentamethyldiethylenetriamine / tetrahydrofuran / 0.33 h / -78 °C
1.2: 3 h / -78 °C
1.3: -78 °C
2.1: sodium amide / tetrahydrofuran / 0.5 h / -78 °C
2.2: -30 - -20 °C
2.3: Cooling with ice
3.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2327.23 Torr
With
N,N,N',N'',N'''-pentamethyldiethylenetriamine; hydrogen; sodium amide;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium amide / tetrahydrofuran / 0.5 h / -78 °C
1.2: -30 - -20 °C
1.3: Cooling with ice
2.1: hydrogen / 20% palladium hydroxide-activated charcoal / methanol / 2327.23 Torr
With
hydrogen; sodium amide;
20% palladium hydroxide-activated charcoal;
In
tetrahydrofuran; methanol;
