450-89-5

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

InChI:InChI=1/C7H6ClFO/c1-10-7-4-5(9)2-3-6(7)8/h2-4H,1H3

Upstream product

• 450-91-9 4-fluoro-2-methoxyaniline 
• 448-19-1 4-fluoro-2-methoxy-1-nitrobenzene 
• 1435-44-5 1-chloro-2,4-difluorobenzene 
• 865-33-8 potassium methanolate 
• 3827-49-4 2-chloro-5-fluoro-phenol 
• 74-88-4 methyl iodide 

Downstream Products

• 102392-11-0 1-(4-fluoro-2-methoxyphenyl)piperazine 
• 698983-69-6 2-chloro-1-(5-chloro-2-fluoro-4-hydroxyphenyl)ethanone 
• 1357103-76-4 3-fluoro-5-methoxy-4-methylaniline 
• 1357103-75-3 N-benzyl-3-fluoro-5-methoxy-4-methylaniline 
• 450-93-1 2-methoxy-4-fluorophenol 
• 1208076-24-7 1-chloro-4-fluoro-2-methoxy-3-methylbenzene 
• 932374-66-8 2-chloro-4-nitro-5-fluoroanisole 

Relevant academic research and scientific papers

N-(SUBSTITUTED-PHENYL)-SULFONAMIDE DERIVATIVES AS KINASE INHIBITORS

The invention relates to N-(substituted-phenyl)-sulfonamide compounds, which are extremely useful as inhibitors of protein kinases (e.g. PERK kinase) and accordingly can be used for the treatment of cell proliferative disorders, such as cancer, or diseases associated with activated unfolded protein response pathways, such as Alzheimer's disease. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

Regioselective SNAr reactions of substituted difluorobenzene derivatives: practical synthesis of fluoroaryl ethers and substituted resorcinols

In this Letter, we describe a practical and highly selective method for the preparation of fluoroaryl ethers and differentially substituted resorcinol derivatives. This synthetic strategy relies on a selective SNAr of substituted difluorobenzen