2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

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Chemical Name:2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid
CAS No.:246179-81-7
Molecular Formula:C₃₇H₃₀N₄O₇
Molecular Weight:642.668
Hs Code.:

Synonyms:2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

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Chemical Property of 2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

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Technology Process of 2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

There total 4 articles about 2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 102774-86-7
9-fluorenylmethyl N-succinimidyl carbonate

: [10-(2-aminoethyl)-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl]acetic acid trifluoroacetic acid salt

: 246179-81-7
2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 4 - 20 ℃; for 1.5h;
DOI:10.1021/ja990466l

Reference yield:

: 208581-36-6
8-benzyloxy-10-[2-({[(tert-butyl)oxy]carbonyl}amino)ethyl]-5-carba-3H,10H-benzo[g]pteridine-2,4-dione

: 246179-81-7
2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / Cs₂CO₃ / dimethylformamide / 5 h / 60 °C

2: 100 percent / H₂O / 3 h / 20 °C

3: 73 percent / aq. K₂CO₃ / dimethylformamide / 1.5 h / 4 - 20 °C

With water; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; 1: Alkylation / 2: Hydrolysis / 3: Acylation;
DOI:10.1021/ja990466l

Reference yield:

: 208581-35-5
6-{[2-({[(tert-butyl)oxy]carbonyl}amino)ethyl]amino}-1H,3H-pyrimidine-2,4-dione

: 246179-81-7
2-{10-[2-({[(fluoren-9-yl)methoxy]carbonyl}amino)ethyl]-8-benzyloxy-2,4-dioxo-5-carba-3H,10H-benzo[g]pteridin-3-yl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / dimethylformamide / 20 h / 120 °C

2: 49 percent / Cs₂CO₃ / dimethylformamide / 5 h / 60 °C

3: 100 percent / H₂O / 3 h / 20 °C

4: 73 percent / aq. K₂CO₃ / dimethylformamide / 1.5 h / 4 - 20 °C

With water; potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide; 1: cyclocondensation / 2: Alkylation / 3: Hydrolysis / 4: Acylation;
DOI:10.1021/ja990466l