tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate
CAS No.:911227-81-1
Molecular Formula:C₃₁H₄₀N₂O₆
Molecular Weight:536.668
Hs Code.:

Synonyms:tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

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Chemical Property of tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

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Technology Process of tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

There total 1 articles about tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 911227-82-2
tert-butyl 5-(methoxymethoxy)-4-(trifluoromethylsulfonyloxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

: 389621-80-1
4-(N,N-diethylaminocarbonyl)phenylboronic acid

: 911227-81-1
tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

Guidance literature:: With sodium carbonate; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; for 10h; Heating / reflux;

Reference yield: 100.0%

: 911227-81-1
tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

: 850173-95-4
N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 16h;

Reference yield:

: 911227-81-1
tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

: C₂₈H₃₄N₂O₃

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C

2: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

3: potassium carbonate / acetone / 90 h / Heating / reflux

4: hydrogenchloride / methanol; diethyl ether / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; acetone;