ADL-5859

Base Information

• Chemical Name: ADL-5859
• CAS No.: 850173-95-4
• Molecular Formula: C₂₄H₂₈N₂O₃*ClH
• Molecular Weight: 428.959
• Mol file: 850173-95-4.mol

Synonyms:ADL5859 HCl;n,n-diethyl-4-(5-hydroxyspiro(2h-1-benzopyran-2,4'-piperidin)-4-yl)benzamide hydrochloride;N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride;ADL-5859;

Chemical Property of ADL-5859

Chemical Property:

• PSA: 61.80000
• LogP: 4.95130
• Solubility.: ≥21.45 mg/mL in DMSO; insoluble in EtOH; ≥5.48 mg/mL in H2O with ultrasonic

Purity/Quality:

97% ^*data from raw suppliers

N,?N-Diethyl-?4-?(5-?hydroxyspiro[2H-?1-?benzopyran-?2,?4''-?piperidin]?-?4-?yl)?-?benzamideHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,?N-Diethyl-?4-?(5-?hydroxyspiro[2H-?1-?benzopyran-?2,?4''-?piperidin]?-?4-?yl)?-?benzamide Hydrochloride is a selective δ-opioid receptor agonist. It is an analgesic and antidepressive agent and a potential drug candidate for treating chronic pain.

Technology Process of ADL-5859

There total 1 articles about ADL-5859 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate (911227-81-1) → N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride (850173-95-4)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 16h;

Reference yield:

N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride (850173-95-4) → C28H34N2O3

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2: potassium carbonate / acetone / 90 h / Heating / reflux

3: hydrogenchloride / methanol; diethyl ether / 16 h / 20 °C

With hydrogenchloride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; diethyl ether; acetone;

Reference yield:

N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide hydrochloride (850173-95-4) → C28H34N2O3*ClH

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 3 h / 0 - 20 °C

2.1: triphenylphosphine / dichloromethane / 0.08 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 16 h / 20 °C

With hydrogenchloride; triethylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane;

upstream raw materials:

tert-butyl 4-(4-(diethylcarbamoyl)phenyl)-5-(methoxymethoxy)spiro[chromene-2,4'-piperidine]-1'-carboxylate

Downstream raw materials:

C₃₃H₄₂N₂O₅

C₃₃H₄₂N₂O₅