(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

Base Information

Chemical Name:(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester
CAS No.:134166-93-1
Molecular Formula:C₃₆H₄₀NO₆PS₂
Molecular Weight:677.822
Hs Code.:

Synonyms:(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

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Chemical Property of (2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

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Technology Process of (2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

There total 3 articles about (2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67941-87-1
cyclohexylammonium S,S-diphenyl phosphorodithioate

: 134166-88-4
(2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyric acid di-p-tolylmethyl ester

: 134166-93-1
(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

Guidance literature:: With pyridine; 1H-tetrazole; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride;
DOI:10.1016/S0040-4039(00)79664-X

Reference yield:

: 2592-18-9
Boc-Thr-OH

: 134166-93-1
(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / 40percent peracetic acid, I₂ / CH₂Cl₂ / 0 °C

2: 88 percent / isodurenedisulfonyl chloride, 1H-tetrazole, pyridine

With pyridine; 1H-tetrazole; peracetic acid; iodine; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; In dichloromethane;
DOI:10.1016/S0040-4039(00)79664-X

Reference yield:

: 55816-25-6
bis(4-methylphenyl)methanone hydrazone

: 134166-93-1
(2S,3R)-3-(Bis-phenylsulfanyl-phosphoryloxy)-2-tert-butoxycarbonylamino-butyric acid di-p-tolylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / 40percent peracetic acid, I₂ / CH₂Cl₂ / 0 °C

2: 88 percent / isodurenedisulfonyl chloride, 1H-tetrazole, pyridine

With pyridine; 1H-tetrazole; peracetic acid; iodine; 2,4,5,6-tetramethylbenzenedisulfonyl dichloride; In dichloromethane;
DOI:10.1016/S0040-4039(00)79664-X