55816-25-6

Usage

Uses

Used in Pharmaceutical Research:
[bis(4-methylphenyl)methylidene]hydrazine is used as a pharmaceutical candidate for its potential antitumor and antiviral activities. It is being studied for its effects on tumor growth and the ability to combat viral infections.
Used in Organic Synthesis:
In the field of organic chemistry, [bis(4-methylphenyl)methylidene]hydrazine is used as a reagent for the preparation of various compounds. Its unique chemical structure allows for the creation of a wide range of molecules with different applications.
Used in Chemical Research:
[bis(4-methylphenyl)methylidene]hydrazine is also utilized in chemical research to study its properties and potential applications in various industries. This includes understanding its solubility, reactivity, and how it can be manipulated to create new compounds with specific uses.

Upstream product

• 611-97-2 bis(p-methylphenyl)-methanone 

Downstream Products

• 1143-91-5 bis(4-methylphenyl)diazomethane 
• 86456-47-5 4,4'-Dimethylbenzophenone dimethyl acetal 
• 4957-14-6 4,4'-dimethyldiphenylmethane 
• 18939-92-9 methyl bis(4-methylphenyl)methyl ether 
• 134166-88-4 (2S,3R)-2-tert-Butoxycarbonylamino-3-hydroxy-butyric acid di-p-tolylmethyl ester 
• 134166-87-3 (S)-2-tert-Butoxycarbonylamino-3-hydroxy-propionic acid di-p-tolylmethyl ester 
• 134166-85-1 (S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionic acid di-p-tolylmethyl ester 
• 5895-68-1 bis-(4,4'-dimethyl-benzhydrylidene)-hydrazine 
• 86456-48-6 Methyl 1-methyl-2,2-bis(4-methylphenyl)cyclopropanecarboxylate 
• 55816-19-8 N²,N⁴-Bis-(4,4'-dimethyldiphenylmethylen)-formohydrazidhydrazon 
• 32188-13-9 C₁₉H₂₄O 

Relevant academic research and scientific papers

Synthesis and physical studies of coumarin-based chemosensor for cyanide ions

A series of novel coumarin-based chemosensor azine derivatives L1, L2 and L3 were synthesized and characterized by various spectroscopic methods such as 1H NMR, mass spectrometry, FT-IR and elemental analysis. The sensing property of the sensor L derivatives was confirmed by the UV–Vis absorption, emission spectra and the naked eye sensing. The sensor L derivatives showed the absorption band at 320–330 nm. The fluorescence emission band was observed at 550–560 nm. In the presence of CN? ions, the chemosensor L derivatives show the “turn-on” fluorescence response over the other competing anions such as Br?, I?, HSO4?, ClO4? and PF6?, and the new absorption band appeared at 385 nm and the emission band also shifted to the blue region at 440 nm. The sensor L derivatives bind to cyanide ions in a 1:1 binding stoichiometry calculated from the job's plot experiments. The detection limit of sensor L1 towards CN? was 5.79 × 10?8 M. Additionally, the binding constant was determined to be 1.0209 × 106 M?1 from the Benesi-Heilbrand equation. The theoretical calculations were performed by Gaussian 9 software. The sensing mechanism of the interaction between the cyanide ion and imine carbon was confirmed by the 1H NMR titration method and mass spectra.

Copper-Mediated Cross-Coupling of Diazo Compounds with Sulfinates

A copper-mediated cross-coupling reaction between a diazo compound and a sodium alkane(arene)sulfinate gives a sulfone as the product. This reaction proceeds under mild conditions and features excellent functional group compatibility. A wide range of sodium alkane(arene)sulfinates were successfully applied in this chemistry. Mechanistic studies revealed that the overall reaction efficiency of the sulfinates was in line with their nucleophilicity in this reaction.

Dehalogenative Cross-Coupling of gem-Difluoroalkenes with Alkyl Halides via a Silyl Radical-Mediated Process

Herein, we describe a convenient general protocol for monofluoroalkenylation reactions of alkyl bromides involving cooperative visible-light photoredox catalysis and halogen abstraction. Mechanistic experiments showed that the products were generated by selective cross-coupling of aliphatic radicals with fluoroalkenyl radicals. Silyl radical-mediated halogen abstraction enabled the protocol to be used for the monofluoroalkenylation of a broad range of alkyl and heteroaryl halides. The protocol could be carried out on a gram scale and was applied to cholesterol, indicating its utility for late-stage monofluoroalkenylation reactions.

Microwave assisted solvent-free C-H amination by silica-supported manganese dioxide

An effective and convenient method has been developed for the preparation of 1-unsubstituted 1H-indazoles via C-H amination of N-acetylhydrazones in the presence of a catalytic amount of manganese dioxide under microwave irradiation. This new method featured easy operation and relatively short reaction-time.

Cu(I)-catalyzed coupling of diaryldiazomethanes with terminal alkynes: An efficient synthesis of tri-aryl-substituted allenes

A highly efficient method for the synthesis of tri-aryl-substituted allenes has been developed through Cu(I)-catalyzed coupling of diaryldiazomethanes with terminal alkynes. The reaction is under mild conditions and uses simple and inexpensive CuI as the catalyst. Mechanistically, the reaction follows a pathway involving Cu(I) carbene migratory insertion.

Cross-Coupling between Difluorocarbene and Carbene-Derived Intermediates Generated from Diazocompounds for the Synthesis of gem-Difluoroolefins

Cross-coupling between difluorocarbene and carbene-derived intermediates generated from diazocompounds was developed to give gem-difluoroolefins, which constitutes a fast practical pathway to achieve hindered gem-difluoroolefins. The cross-coupling between difluorocarbene and aryl diazoacetates proceeded smoothly in the presence of a copper source, whereas its coupling with diaryl diazomethanes occurred well under metal-free conditions. A mechanism involving a copper-difluorocarbene complex was proposed.

Microwave induced synthesis of hydrazones and Wolff-Kishner reduction of carbonyl compounds

Carbonyl compounds 1 are converted to hydrazones 3 and then to hydrocarbons 4 by Wolff-Kishner reductions under microwave irradiations within 25-30 mins in excellent yields.