(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Base Information

Chemical Name:(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate
CAS No.:143761-33-5
Molecular Formula:C₂₈H₃₉ClN₂O₆S
Molecular Weight:567.146
Hs Code.:

(4R)-methyl 8-<N-<(4-chlorophenyl)sulfonyl>-N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Synonyms:(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Suppliers and Price of (4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

There total 13 articles about (4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 133033-79-1
N-(tert-butoxycarbonyl)-4-chlorobenzenesulfonamide

: 145746-81-2
(4R)-methyl 8-hydroxy-4-<3-(3-pyridinyl)propyl>octanoate

: 143761-33-5
(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In dichloromethane; for 1.16667h;
DOI:10.1021/jm00054a003

Reference yield:

: 626-55-1,163928-56-1
3-Bromopyridine

: 143761-33-5
(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 9-BBN, 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, K₃PO₄ / 1.) THF, RT, 18 h, 2.) THF, reflux, 47 h

2: 92 percent / 20percent palladium hydroxide/C / cyclohexane / 25 h / Heating

3: 100 percent / Ph₃P, diethyl azodicarboxylate (DEAD) / CH₂Cl₂ / 1.17 h

With potassium phosphate; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium hydroxide - carbon; triphenylphosphine; diethylazodicarboxylate; In dichloromethane; cyclohexane;
DOI:10.1021/jm00054a003

Reference yield:

: 130892-97-6
6-benzyloxyhexanoic acid

: 143761-33-5
(4R)-methyl 8--N-(tert-butoxycarbonyl)amino>-4-<3-(3-pyridinyl)propyl>octanoate

Guidance literature:: Multi-step reaction with 12 steps

1: Et₃N / diethyl ether / 2 h / 0 °C

2: 1.) n-BuLi / 1.) THF, hexane, 2.) THF, from -78 deg to RT, 1 h

3: 1.) LDA / 1) THF, hexane, -78 deg C, 30 min, 2.) THF, hexane, -10 deg C, 2 h

4: 83 percent / LiBH₄, H₂O / diethyl ether; tetrahydrofuran / 0.5 h / 0 - 20 °C

5: 100 percent / Et₃N / CH₂Cl₂ / 2 h / 0 °C

6: 1.) NaH / 1.) THF, RT, 30 min, 2.) THF, reflux, 18 h

7: aq. KOH / dioxane / 18 h / Ambient temperature

8: 3 h / 125 - 140 °C

9: diethyl ether / 0.17 h / 0 °C

10: 1.) 9-BBN, 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾, K₃PO₄ / 1.) THF, RT, 18 h, 2.) THF, reflux, 47 h

11: 92 percent / 20percent palladium hydroxide/C / cyclohexane / 25 h / Heating

12: 100 percent / Ph₃P, diethyl azodicarboxylate (DEAD) / CH₂Cl₂ / 1.17 h

With potassium hydroxide; potassium phosphate; lithium borohydride; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; palladium hydroxide - carbon; water; sodium hydride; triethylamine; triphenylphosphine; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; cyclohexane;
DOI:10.1021/jm00054a003