130892-97-6

Upstream product

• 502-44-3 hexahydro-2H-oxepin-2-one 
• 100-44-7 benzyl chloride 
• 70388-33-9 4-benzyloxybut-1-ene 
• 122-59-8 2-phenoxyacetic acid 
• 629-11-8 1,6-hexanediol 
• 100-39-0 benzyl bromide 
• 101492-91-5 6-benzyloxy-1-hexanal 
• 1191-25-9 6-Hydroxyhexanoic acid 
• 100-52-7 benzaldehyde 
• 71126-73-3 6-benzyloxyhexan-1-ol 

Downstream Products

• 145122-86-7 5-(6'-Benzyloxy-1'-hydroxyhexylidene)-2,2-dimethyl-1,3-dioxan-4,6-dione 
• 162439-38-5 6-benzyloxyhexanoic acid chloride 
• 201743-96-6 6-Benzyloxy-2-[((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-hexanoic acid methyl ester 
• 1424403-24-6 (5R,7R)-methyl 7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoate 
• 1424403-25-7 (R)-(3R,5R)-2,2,5-trimethyl-9-(methylamino)-9-oxononan-3-yl 6-(benzyloxy)-2-methylhexanoate 
• 1424403-17-7 (5R,7R)-7-(((R)-6-(benzyloxy)-2-methylhexanoyl)oxy)-5,8,8-trimethylnonanoic acid 
• 1424403-08-6 C₂₇H₄₄O₅ 
• 1424403-09-7 C₂₇H₄₄O₅ 
• 1424403-15-5 C₂₇H₄₄O₅ 
• 1424403-16-6 C₂₇H₄₄O₅ 
• 1424403-34-8 (+)-(R)-7-(benzyloxy)-3-methylheptanal 
• 1424403-04-2 (R)-4-benzyl-3-((R)-6-(benzyloxy)-2-methylhexanoyl)oxazolidin-2-one 
• 1424403-05-3 (R)-6-(benzyloxy)-2-methylhexanoic acid 
• 1424403-20-2 (R)-methyl 7-(benzyloxy)-3-methylheptanoate 

Relevant academic research and scientific papers

Total synthesis of 26-fluoro-epothilone B

An efficient synthesis of the epothilone B derivative 26-fluoroepothilone B (1) was realized by early introduction of the synthetically demanding fluoromethyl epoxide function. The presence of a fluoro substituent results in a remarkable increase in the stability of the epoxide, which tolerates the wide range of reaction conditions required for the fragment coupling step and end game transformations.

Manganese(III)-based oxidative freeradical reaction of α-allyl-β-keto ester with molecular oxygen

Oxidative reactions of α-allyl-β-keto esters 5 with Mn(OAc)3·2H2O give the δ-hydroxy-β-,γ-unsaturated-α-keto esters 6 in good yields. The mechanism of this reaction is discussed.

FIBER COATED NANOPORES

Provided herein are compositions, compounds, processes, and methods of use of 3D porous coating(s) on or near a nanopore(s) for analysis or detection of charged polymers such as nucleic acids, proteins, protein-nucleic acid complexes, small molecule-biological complexes, polymer-biological complexes, and/or polyelectrolytes.

Liquid crystal compound, liquid crystal composition, polymer and application

The invention a liquid crystal compound, a liquid crystal composition and a polymer and application which can suppress refractive index anisotropism due to wave lengths, display low wavelength dispersion characteristics and further display inverse wavelength dispersion. The invention discloses the compound expressed by the formula (1) and the liquid crystal composition containing the compound.

Total synthesis of palmyrolide A and its 5,7-epi isomers

Stereoselective total synthesis of palmyrolide A, a 15-membered neuroactive macrolide, was described by adopting a synthetic strategy developed for the proposed structures, and its 5,7-epi isomers. The strategy was designed in such a way that the set of s

Triflic acid catalyzed reductive coupling reactions of carbonyl compounds with O-, S-, and N-nucleophiles

Highly efficient metal-free reductive coupling reactions of aldehydes and ketones with a range of nucleophiles in the presence of triflic acid (1-5 mol %) as the catalyst are presented. The reactions can be performed at ambient temperature without exclusion of moisture or air. A range of symmetrical and unsymmetrical ethers were obtained by this method in high yields and short reaction times. For the first time, the influence of additional functionalization has been studied. Furthermore, the formation of thioethers from ketones (by addition of unmodified thiols) and of sulfonamides from either aldehydes or ketones has been achieved under catalytic conditions.

Films and Particles

Described herein are compounds and processes that can be used to prepare polymer-based films, particles, gels and related compositions, and processes for delivery of agents, and other uses.

Water solubility, antioxidant activity and cytochrome C binding of four families of exohedral adducts of C60 and C70

Over the past decade, surface-modified, water soluble fullerenes have been shown by many different investigators to exhibit strong antioxidant activity against reactive oxygen species (ROS) in vitro and to protect cells and tissues from oxidative injury a

A NEW PROCESS FOR THE PREPARATION OF EPOTHILONE DERIVATIVES, NEW EPOTHILONE DERIVATIVES AS WELL AS NEW INTERMEDIATE PRODUCTS FOR THE PROCESS AND THE METHODS OF PREPARING SAME

The present invention provides a synthesis for the preparation of epothilone derivatives of formula (9) wherein R1 is methyl, and R2 has the meaning of an unsubstituted or substituted aryl, an unsubstituted or substituted heteroaryl or an unsubstituted or substituted heterocyclic radical fused to a benzene nucleus, and salts thereof, and intermediates for the synthesis of a compound of formula (9).

Synthesis of a D-lactosyl cluster-nucleoside conjugate

The synthesis of a nucleoside-oligolactoside conjugate, expected to provide site-specific drug delivery to the human liver, is described.