N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

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Chemical Name:N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide
CAS No.:1087353-14-7
Molecular Formula:C₁₉H₁₈FN₅O₂S₂
Molecular Weight:431.515
Hs Code.:

Synonyms:N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

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Chemical Property of N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

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Technology Process of N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

There total 10 articles about N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.5%

: 1087352-62-2
N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-acetamide

: 1087353-14-7
N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

Guidance literature:: With Lawessons reagent; In 1,4-dioxane; at 60 ℃; for 0.333333h;

Reference yield:

: 324789-64-2
2-fluoro-4-(5-methanesulfonyloxymethyl-2-oxo-oxazolidin-3-yl)-benzoic acid tert-butyl ester

: 1087353-14-7
N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium azide / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

3.1: thionyl chloride / dichloromethane / 3 h / 60 °C

3.2: 2 h / 0 - 20 °C

4.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

4.2: 5 h / 90 °C / Heating / reflux

5.1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

6.1: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

7.1: toluene / 2 h / 110 °C / Heating / reflux

8.1: potassium carbonate / acetonitrile / 4 h / 75 °C

9.1: trifluoroacetic acid / dichloromethane / 1 h

9.2: 1 h / 0 - 20 °C

10.1: Lawessons reagent / 1,4-dioxane / 0.33 h / 60 °C

With Lawessons reagent; thionyl chloride; sodium azide; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 324789-26-6
4-(5-azidomethyl-2-oxo-oxazolidin-3-yl)-2-fluoro-benzamide

: 1087353-14-7
N-{3-[3-fluoro-4-(4-imidazol-1-ylmethyl-thiazol-2-yl)-phenyl]-2-oxo-oxazolidin-5(S)-ylmethyl}-thioacetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

1.2: 5 h / 90 °C / Heating / reflux

2.1: triethylamine / tetrahydrofuran; methanol / 0 - 20 °C

3.1: Lawessons reagent / 1,4-dioxane / 1 h / 60 °C

4.1: toluene / 2 h / 110 °C / Heating / reflux

5.1: potassium carbonate / acetonitrile / 4 h / 75 °C

6.1: trifluoroacetic acid / dichloromethane / 1 h

6.2: 1 h / 0 - 20 °C

7.1: Lawessons reagent / 1,4-dioxane / 0.33 h / 60 °C

With Lawessons reagent; potassium carbonate; triethylamine; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;