2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine

Base Information

• Chemical Name: 2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine
• CAS No.: 928312-62-3
• Molecular Formula: C₃₂H₃₁NO₆
• Molecular Weight: 525.601
• Mol file: 928312-62-3.mol

Synonyms:2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine

Chemical Property of 2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine

There total 1 articles about 2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2-(2-O,4-C-methylene-β-D-ribofuranosyl)pyridine → 2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine (928312-62-3)

Guidance literature:

With pyridine; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c004895j

Reference yield: 89.0%

2-[5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine (928312-62-3) + N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite (102691-36-1) → 2-[3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine (928312-65-6)

Guidance literature:

With N,N-diisopropylamine tetrazolide; In tetrahydrofuran; acetonitrile; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c004895j

upstream raw materials:

4,4'-dimethoxytrityl chloride

Downstream raw materials:

2-[3-O-[2-cyanoethoxy(diisopropylamino)phosphino]-5-O-(4,4'-dimethoxytrityl)-2-O,4-C-methylene-β-D-ribofuranosyl]pyridine