ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate
CAS No.:1095274-48-8
Molecular Formula:C₁₇H₂₃ClN₄O₄
Molecular Weight:382.847
Hs Code.:

Synonyms:ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

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Chemical Property of ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

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Technology Process of ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

There total 5 articles about ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 896466-67-4
3-chloro-5-(4-methylpiperazin-1-yl)benzonitrile

: 1095274-48-8
ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / ethanol; water / 2.5 h / Heating / reflux

2.1: sulfuric acid / 96 h / Heating / reflux

2.2: 20 °C / pH 7 - 8

3.1: hydrazine / ethanol / 4 h / Heating / reflux

4.1: tetrahydrofuran / 0.5 h / 20 °C

With sodium hydroxide; sulfuric acid; hydrazine; In tetrahydrofuran; ethanol; water;

Reference yield:

: 327056-73-5
3-fluoro-5-chlorobenzonitrile

: 1095274-48-8
ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 - 80 °C

2.1: sodium hydroxide / ethanol; water / 2.5 h / Heating / reflux

3.1: sulfuric acid / 96 h / Heating / reflux

3.2: 20 °C / pH 7 - 8

4.1: hydrazine / ethanol / 4 h / Heating / reflux

5.1: tetrahydrofuran / 0.5 h / 20 °C

With sodium hydroxide; sulfuric acid; potassium carbonate; hydrazine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1095274-48-8
ethyl 3-(2-{[3-chloro-5-(4-methyl-1-piperazinyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 20 - 80 °C

2.1: sodium hydroxide / ethanol; water / 2.5 h / Heating / reflux

3.1: sulfuric acid / 96 h / Heating / reflux

3.2: 20 °C / pH 7 - 8

4.1: hydrazine / ethanol / 4 h / Heating / reflux

5.1: tetrahydrofuran / 0.5 h / 20 °C

With sodium hydroxide; sulfuric acid; potassium carbonate; hydrazine; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;