(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester
CAS No.:174579-28-3
Molecular Formula:C₂₅H₃₈Cl₂N₂O₄S
Molecular Weight:533.56
Hs Code.:

Synonyms:(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

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Chemical Property of (S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

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Technology Process of (S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

There total 5 articles about (S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 156079-52-6
(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-acetylamino)-pentanedioic acid di-tert-butyl ester

: 174579-28-3
(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

Guidance literature:: With Lawessons reagent; In dichloromethane; for 18h; Ambient temperature;
DOI:10.1021/jm950671l

Reference yield:

: 16874-06-9
di-tert-butyl L-glutamate

: 174579-28-3
(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 77 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / dimethylformamide / 18 h / Ambient temperature

2: 90 percent / H₂ / 30percent Pd/C / ethyl acetate

3: 6.3 g / aq. glacial acetic acid / 24 h / Ambient temperature

4: 42 percent / methanesulfonyl chloride, pyridine / 1 h / 80 °C

5: 80 percent / Lawesson's reagent / CH₂Cl₂ / 18 h / Ambient temperature

With Lawessons reagent; pyridine; hydrogen; benzotriazol-1-ol; acetic acid; methanesulfonyl chloride; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm950671l

Reference yield:

: 156079-53-7
(S)-2-[2-(4-Nitro-phenyl)-acetylamino]-pentanedioic acid di-tert-butyl ester

: 174579-28-3
(S)-2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-thioacetylamino)-pentanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂ / 30percent Pd/C / ethyl acetate

2: 6.3 g / aq. glacial acetic acid / 24 h / Ambient temperature

3: 42 percent / methanesulfonyl chloride, pyridine / 1 h / 80 °C

4: 80 percent / Lawesson's reagent / CH₂Cl₂ / 18 h / Ambient temperature

With Lawessons reagent; pyridine; hydrogen; acetic acid; methanesulfonyl chloride; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm950671l