16874-06-9

Basic information

• Product Name: L-GLUTAMIC ACID DI-TERT-BUTYLESTER DIBEN ZENESULFIMIDE SALT
• Synonyms: bis(tert-butyl) L-glutamate;Glutamicaciddi-tert-butylesterdibenzenesulfimidesalt;di-tert-butyl glutamate;L-glutamic acid di-tert-butyl ester dibenzenesulfimide;L-Glutamic acid di-tert-butyl ester dibenzenesulfonimide salt;L-Glutamic acid bis(1,1-dimethylethyl) ester;Einecs 240-900-2;L-GlutaMic acid di-tert-butyl ester
• CAS NO: 16874-06-9
• Molecular Formula: C₁₃H₂₅NO₄
• Molecular Weight: 259.3419
• EINECS: 240-900-2
• Product Categories: Amino Acid Derivatives;Glutamic Acid;Peptide Synthesis
• Mol File: 16874-06-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 139-141 °C (dec.)
• Boiling Point: 311.1°Cat760mmHg
• Flash Point: 78.1°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.000574mmHg at 25°C
• Refractive Index: 1.457
• PKA: 6.85±0.35(Predicted)
• CAS DataBase Reference: L-GLUTAMIC ACID DI-TERT-BUTYLESTER DIBEN ZENESULFIMIDE SALT(CAS DataBase Reference)
• NIST Chemistry Reference: L-GLUTAMIC ACID DI-TERT-BUTYLESTER DIBEN ZENESULFIMIDE SALT(16874-06-9)
• EPA Substance Registry System: L-GLUTAMIC ACID DI-TERT-BUTYLESTER DIBEN ZENESULFIMIDE SALT(16874-06-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 16874-06-9(Hazardous Substances Data)

Usage

General Description

L-glutamic acid di-tert-butylester dibenzene sulfimide salt is a compound that is formed by the reaction of L-glutamic acid di-tert-butylester and dibenzene sulfimide. It is commonly used as a chemical intermediate in the synthesis of various organic compounds. L-GLUTAMIC ACID DI-TERT-BUTYLESTER DIBEN ZENESULFIMIDE SALT is often used in organic and medicinal chemistry research due to its ability to undergo various reactions and form different products. It is also used as a building block in the synthesis of peptides and other biologically active compounds. Additionally, it has potential applications in the pharmaceutical industry for the development of new drugs.

InChI:InChI=1/C13H25NO4/c1-12(2,3)17-10(15)8-7-9(14)11(16)18-13(4,5)6/h9H,7-8,14H2,1-6H3/t9-/m0/s1

Upstream product

• 32677-01-3 L-glutamic acid di-tert-butyl ester hydrochloride 
• 540-88-5 acetic acid tert-butyl ester 
• 56-86-0 L-glutamic acid 
• 86491-34-1 Di-tert-butyl α-ketoglutarate 
• 1197815-07-8 C₃₉H₅₅N₃O₁₁Se 
• 1155-62-0 N-benzyloxycarbonyl-L-glutamic acid 
• 115-11-7 isobutene 
• 16881-41-7 di-tert-butyl N-Cbz-L-glutamate 

Downstream Products

• 32719-56-5 tri-tert-butyl N--L-glutamate 
• 124688-46-6 N-<4-(N-Cbz-D,L-erythro,threo-5-oxo-4-oxazolidinyl)-2-fluoropropionyl>-L-glutamic acid di-tert-butyl ester 
• 87597-84-0 di-tert-butyl N-(4-formylbenzoyl)-L-glutamate 
• 113035-38-4 Boc-L-Phe-L-Glu(OtBu)-OtBu 
• 120296-66-4 di-tert-butyl-5-chloro-N¹⁰-(trifluoroacetyl)-5,8-dideazafolate 
• 156079-53-7 (S)-2-[2-(4-Nitro-phenyl)-acetylamino]-pentanedioic acid di-tert-butyl ester 
• 197223-37-3 tert-butyl (2S)-2-(benzyloxycarbonylamino)-5-[(1S)-1,3-di(tert-butoxycarbonyl)propylamino]pentanoate 
• 875667-98-4 di-tert-butyl N-[4-(N-benzyloxycarbonyl-N-methyl)aminobenzoyl]-L-glutamate 
• 56-86-0 L-glutamic acid 
• 2419-56-9 L-glutamic acid 5-tert-butyl ester 
• 45120-30-7 L-glutamic acid α-tert-butyl ester 
• 1197815-08-9 C₂₉H₃₈N₂O₈Se 
• 1197815-06-7 C₂₅H₃₈N₂O₈Se 
• 1025796-30-8 (S)-2-[3-((S)-(5-benzyloxycarbonylamino)-1-tert-butoxycarbonylpentyl)ureido]pentanedioic acid di-tert-butyl ester 

Relevant articles and documents

Radiosynthesis of novel N-18F-labeled 18F-FHex-α-l-Glu and 18F-FHex-β-Glu

N-18F-labeled amino acids are important substitutes for new positron emission tomography (PET) imaging tracers complementing the deficiency of 18F-fluorodeoxyglucose (18F-FDG). In this work, two novel N-6-18F-alkyl amino acid imaging agents, 18F-FHex-α-l-Glu and 18F-FHex-β-Glu, were designed and synthesized as potential probes for PET imaging of tumors. 18F-FHex-α-l-Glu was synthesized using the precursor 6 from 18F-F? with the yield of 16 ± 4% (n = 5, uncorrected) within about 50 minutes. The specific activity was 14.5 GBq/μmol, and the radiochemical purity was more than 95%. 18F-FHex-β-Glu was synthesized using the precursor 12 based on 18F-F? with the yield of 11 ± 3% (n = 3, uncorrected) in about 60 minutes. The specific activity was 9.1 GBq/μmol, and the radiochemical purity was more than 95%.

Asymmetric Synthesis of α-Amino Acids by Organocatalytic Biomimetic Transamination

A biomimetic enantioselective transamination of α-keto ester derivatives can be realized under mild conditions by using chiral quaternary ammonium arenecarboxylates in the absence of base additives. The corresponding α-amino acids can be used as versatile intermediates for further synthetic transformations that furnish chiral pyrrolidine and octahydroindolizine derivatives.

A selenide-based approach to photochemical cleavage of peptide and protein backbones at engineered backbone esters

(Chemical Equation Presented) A strategy for photochemical cleavage of peptide and protein backbones is described, which is based on a selenide-mediated cleavage of a backbone ester moiety. Studies in model systems establish the viability of the chemistry