(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate
CAS No.:1146162-26-6
Molecular Formula:C₂₃H₂₅BrN₄O₃
Molecular Weight:485.38
Hs Code.:

Synonyms:(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

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Chemical Property of (S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

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Technology Process of (S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

There total 6 articles about (S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262849-76-2
2-(5-bromo-2-methoxyphenyl)-4-chloroquinazoline

: 1146162-26-6
(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 16 h / 20 °C

2: triethylamine / N,N-dimethyl acetamide

With boron tribromide; triethylamine; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm101150b

Reference yield:

: 1262849-75-1
2-(5-bromo-2-methoxyphenyl)-4-hydroxyquinazoline

: 1146162-26-6
(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 20 h / Reflux

2: boron tribromide / dichloromethane / 16 h / 20 °C

3: triethylamine / N,N-dimethyl acetamide

With boron tribromide; triethylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl acetamide;
DOI:10.1021/jm101150b

Reference yield:

: 461422-05-9
C₁₅H₁₁BrN₂O₂

: 1146162-26-6
(S)-tert-butyl 3-(2-(5-bromo-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; sodium hydroxide / 1,4-dioxane; water / 20 h / 100 °C

2: trichlorophosphate / 20 h / Reflux

3: boron tribromide / dichloromethane / 16 h / 20 °C

4: triethylamine / N,N-dimethyl acetamide

With dihydrogen peroxide; boron tribromide; triethylamine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;
DOI:10.1021/jm101150b