1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

Base Information

Chemical Name:1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one
CAS No.:1393847-40-9
Molecular Formula:C₁₄H₁₆N₂O₂S₂
Molecular Weight:308.425
Hs Code.:

Synonyms:1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

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Chemical Property of 1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

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Technology Process of 1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

There total 5 articles about 1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 132774-39-1
1-(ethoxymethyl)-6-(phenylthio)thymine

: 1393847-40-9
1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

Guidance literature:: With Lawessons reagent; In toluene; for 2h; Reflux;
DOI:10.1016/j.ejmech.2012.04.038

Reference yield:

: 2417-22-3,697787-37-4
5-methylbarbituric acid

: 1393847-40-9
1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate / 7 h / 50 °C / Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 °C / Inert atmosphere

3.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

4.1: Lawessons reagent / toluene / 2 h / Reflux

With Lawessons reagent; sodium tetrahydroborate; N,O-bis-(trimethylsilyl)-acetamide; N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate; In methanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.04.038

Reference yield:

: 1627-28-7
6-chloro-5-methylpyrimidine-2,4(1H,3H)-dione

: 1393847-40-9
1-ethoxymethyl-3,4-dihydro-5-methyl-6-(phenylthio)-4-thioxopyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,O-bis-(trimethylsilyl)-acetamide / dichloromethane / 2 h / 20 °C / Inert atmosphere

1.2: 2 h / 0 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

3.1: Lawessons reagent / toluene / 2 h / Reflux

With Lawessons reagent; sodium tetrahydroborate; N,O-bis-(trimethylsilyl)-acetamide; In methanol; dichloromethane; toluene;
DOI:10.1016/j.ejmech.2012.04.038