tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

Base Information

Chemical Name:tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate
CAS No.:117605-21-7
Molecular Formula:C₄H₄O₄*C₂₉H₃₇N₃O₆
Molecular Weight:639.703
Hs Code.:

tert-butyl (4S)-3-<(2S)-2-<N-((1S)-1-benzyloxycarbonyl-3-phenylpropyl)amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

Synonyms:tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

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Chemical Property of tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

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Technology Process of tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

There total 13 articles about tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77999-24-7
(S)‐2‐oxoimidazolidine‐1,5‐dicarboxylate-5‐tert‐butyl ester-1‐benzyl ester

: 117605-21-7
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

Guidance literature:: Multi-step reaction with 4 steps

1: 89.8 percent / K₂CO₃ / acetone / 72 h / Ambient temperature

2: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

3: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min

4: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature

With potassium tert-butylate; hydrogen; potassium carbonate; palladium; In methanol; di-isopropyl ether; ethyl acetate; acetone;
DOI:10.1021/jm00122a003

Reference yield:

: 83056-78-4
tert-butyl (4S)-3-(benzyloxycarbonyl)-1-methyl-2-oxoimidazolidine-4-carboxylate

: 117605-21-7
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

Guidance literature:: Multi-step reaction with 3 steps

1: 98.2 percent / H₂ / Pd / methanol / 3 h / 760 Torr / Ambient temperature

2: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min

3: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature

With potassium tert-butylate; hydrogen; palladium; In methanol; di-isopropyl ether; ethyl acetate;
DOI:10.1021/jm00122a003

Reference yield:

: 16503-46-1
2-bromo-4-phenyl butanoic acid

: 117605-21-7
tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate

Guidance literature:: Multi-step reaction with 10 steps

1: 28percent aq. NH₃ / 168 h / Ambient temperature

3: CoCl₂ / H₂O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7

4: benzene / 6 h / Heating

5: 40.8 percent / K₂CO₃ / dimethylsulfoxide / 30 h / Ambient temperature

6: ethyl acetate; diisopropyl ether

7: 94 percent / 15percent HCl/dioxane / Ambient temperature

8: DCC / tetrahydrofuran / Ambient temperature

9: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min

10: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature

With hydrogenchloride; ammonium hydroxide; potassium tert-butylate; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1021/jm00122a003