Technology Process of tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate
There total 13 articles about tert-butyl (4S)-3-<(2S)-2-propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylate hydrogen maleate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 89.8 percent / K2CO3 / acetone / 72 h / Ambient temperature
2: 98.2 percent / H2 / Pd / methanol / 3 h / 760 Torr / Ambient temperature
3: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
4: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature
With
potassium tert-butylate; hydrogen; potassium carbonate;
palladium;
In
methanol; di-isopropyl ether; ethyl acetate; acetone;
DOI:10.1021/jm00122a003
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 98.2 percent / H2 / Pd / methanol / 3 h / 760 Torr / Ambient temperature
2: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
3: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature
With
potassium tert-butylate; hydrogen;
palladium;
In
methanol; di-isopropyl ether; ethyl acetate;
DOI:10.1021/jm00122a003
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 28percent aq. NH3 / 168 h / Ambient temperature
3: CoCl2 / H2O / 72 h / 37 °C / aminoacylase (from Aspergillus oryzae); pH 7
4: benzene / 6 h / Heating
5: 40.8 percent / K2CO3 / dimethylsulfoxide / 30 h / Ambient temperature
6: ethyl acetate; diisopropyl ether
7: 94 percent / 15percent HCl/dioxane / Ambient temperature
8: DCC / tetrahydrofuran / Ambient temperature
9: 1) tBuOK / 1) THF, -50 deg C, 20 min, 2) THF, -30 deg C, 20 min
10: ethyl acetate; diisopropyl ether / 3 h / Ambient temperature
With
hydrogenchloride; ammonium hydroxide; potassium tert-butylate; potassium carbonate; dicyclohexyl-carbodiimide;
In
tetrahydrofuran; di-isopropyl ether; water; dimethyl sulfoxide; ethyl acetate; benzene;
DOI:10.1021/jm00122a003
