N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

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Chemical Name:N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide
CAS No.:773155-82-1
Molecular Formula:C₃₂H₄₅F₃N₂O₅Si
Molecular Weight:622.8
Hs Code.:

<i>N</i>-(4-benzyl-2-oxo-oxazolidin-3-yl)-<i>N</i>-[3-benzyloxy-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

Synonyms:N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

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Chemical Property of N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

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Technology Process of N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

There total 6 articles about N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 773155-73-0
(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

: 407-25-0
trifluoroacetic anhydride

: 773155-82-1
N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

Guidance literature:: With dmap; In triethylamine; at 0 - 20 ℃;
DOI:10.1021/ol048986v

Reference yield:

: 773155-71-8
3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyraldehyde

: 773155-82-1
N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 99 percent / p-toluenesulfonic acid; 4 angstroem molecular sieves / CH₂Cl₂ / 20 °C

2.1: InCl₃; Mn₂(CO)10 / CH₂Cl₂ / 18 h / 20 - 35 °C / UV-irradiation

2.2: 77 percent / NEt₃ / CH₂Cl₂ / 3 h

3.1: 71 percent / DMAP / triethylamine / 0 - 20 °C

With dmap; indium(III) chloride; dimanganese decacarbonyl; 4 A molecular sieve; toluene-4-sulfonic acid; In dichloromethane; triethylamine;
DOI:10.1021/ol048986v

Reference yield:

: 773155-80-9
(2-benzyloxy-pent-4-enyloxy)-tert-butyl-dimethyl-silane

: 773155-82-1
N-(4-benzyl-2-oxo-oxazolidin-3-yl)-N-[3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butyl]-2,2,2-trifluoro-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: NMO; OsO₄ / tetrahydrofuran; H₂O; 2-methyl-propan-2-ol / 0 - 20 °C

1.2: 93 percent / NaHCO₃; NaIO₄ / H₂O / 0 - 20 °C

2.1: 99 percent / p-toluenesulfonic acid; 4 angstroem molecular sieves / CH₂Cl₂ / 20 °C

3.1: InCl₃; Mn₂(CO)10 / CH₂Cl₂ / 18 h / 20 - 35 °C / UV-irradiation

3.2: 77 percent / NEt₃ / CH₂Cl₂ / 3 h

4.1: 71 percent / DMAP / triethylamine / 0 - 20 °C

With dmap; indium(III) chloride; osmium(VIII) oxide; N-methyl-2-indolinone; dimanganese decacarbonyl; 4 A molecular sieve; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; water; triethylamine; tert-butyl alcohol;
DOI:10.1021/ol048986v