(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

Base Information

Chemical Name:(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one
CAS No.:773155-73-0
Molecular Formula:C₃₀H₄₆N₂O₄Si
Molecular Weight:526.792
Hs Code.:

Synonyms:(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

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Chemical Property of (S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

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Technology Process of (S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

There total 6 articles about (S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 75-30-9
2-iodo-propane

: C₂₇H₃₈N₂O₄Si

: 773155-73-0
(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

Guidance literature:: With indium(III) chloride; dimanganese decacarbonyl; In dichloromethane; Irradiation; Inert atmosphere;
DOI:10.1021/acs.joc.1c01798

Reference yield: 77.0%

: (S)-4-Benzyl-3-[(R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-but-(E)-ylideneamino]-oxazolidin-2-one

: 75-30-9
2-iodo-propane

: 773155-73-0
(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

Guidance literature:: (S)-4-Benzyl-3-[(R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-but-(E)-ylideneamino]-oxazolidin-2-one; 2-iodo-propane; With indium(III) chloride; dimanganese decacarbonyl; In dichloromethane; at 20 - 35 ℃; for 18h; UV-irradiation;

With triethylamine; In dichloromethane; for 3h;
DOI:10.1021/ol048986v

Reference yield:

: 773155-71-8
3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-butyraldehyde

: 773155-73-0
(S)-4-Benzyl-3-[(1R,3R)-3-benzyloxy-4-(tert-butyl-dimethyl-silanyloxy)-1-isopropyl-butylamino]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / p-toluenesulfonic acid; 4 angstroem molecular sieves / CH₂Cl₂ / 20 °C

2.1: InCl₃; Mn₂(CO)10 / CH₂Cl₂ / 18 h / 20 - 35 °C / UV-irradiation

2.2: 77 percent / NEt₃ / CH₂Cl₂ / 3 h

With indium(III) chloride; dimanganese decacarbonyl; 4 A molecular sieve; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1021/ol048986v