(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

Base Information

Chemical Name:(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide
CAS No.:146651-57-2
Molecular Formula:C₄₆H₄₄N₂O₆
Molecular Weight:720.865
Hs Code.:

Synonyms:(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

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Chemical Property of (1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

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Technology Process of (1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

There total 7 articles about (1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17690-16-3
benzyl bromomethyl ether

: 146651-57-2
(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA

2: KOH / ethanol / Heating

3: xylene / Heating

4: aq. NH₃

5: SOCl₂

6: pyridine

With pyridine; potassium hydroxide; ammonium hydroxide; thionyl chloride; lithium diisopropyl amide; In ethanol; xylene;
DOI:10.1021/ja00055a066

Reference yield:

: 52831-11-5
trimethyl cyclohexane-1,3,5-tricarboxylate

: 146651-57-2
(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) LDA

2: KOH / ethanol / Heating

3: xylene / Heating

4: aq. NH₃

5: SOCl₂

6: pyridine

With pyridine; potassium hydroxide; ammonium hydroxide; thionyl chloride; lithium diisopropyl amide; In ethanol; xylene;
DOI:10.1021/ja00055a066

Reference yield:

: 146651-50-5
1,3,5-Tris-benzyloxymethyl-cyclohexane-1,3,5-tricarboxylic acid trimethyl ester

: 146651-57-2
(1R,5S,7R)-1,5,7-Tris-benzyloxymethyl-2,4-dioxo-3-aza-bicyclo[3.3.1]nonane-7-carboxylic acid (9H-fluoren-2-yl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: KOH / ethanol / Heating

2: xylene / Heating

3: aq. NH₃

4: SOCl₂

5: pyridine

With pyridine; potassium hydroxide; ammonium hydroxide; thionyl chloride; In ethanol; xylene;
DOI:10.1021/ja00055a066