4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

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Chemical Name:4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester
CAS No.:281219-45-2
Molecular Formula:C₃₀H₄₂N₄O₅
Molecular Weight:538.687
Hs Code.:

Synonyms:4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

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Chemical Property of 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

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Technology Process of 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

There total 6 articles about 4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 51061-68-8
3-(pyridin-2-yl)-phenyl acetic acid

: 281219-35-0
4(R,S)-[(S)-1-(3(R,S)-hydroxyazepan-4-ylcarbamoyl)-3-methylbutyl]carbamic acid tert-butyl ester

: 281219-45-2
4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm000481x

Reference yield:

: 150989-62-1
2,3,4,7-tetrahydro-azepine-1-carboxylic acid benzyl ester

: 281219-45-2
4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: m-CPBA / CH₂Cl₂ / 0.25 h / 5 °C

2.1: NaN₃; NH₄Cl / H₂O; methanol / 70 °C

2.2: 61 percent / Et₃N; 1,3-propanedithiol / methanol / 20 °C

3.1: 77 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

4.1: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

5.1: 86 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

With sodium azide; hydrogen; ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 3-chloro-benzenecarboperoxoic acid; 10percent Pd/C; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm000481x

Reference yield:

: 150989-59-6
8-oxo-3-azabicyclo[5.1.0]octane-3-carboxylic acid benzyl ester

: 281219-45-2
4(R,S)-((S)-1-{3(R,S)-hydroxy-1-[2-(3-pyridin-2-ylphenyl)ethanoyl]azepan-4-ylcarbamoyl}-3-methylbutyl)carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaN₃; NH₄Cl / H₂O; methanol / 70 °C

1.2: 61 percent / Et₃N; 1,3-propanedithiol / methanol / 20 °C

2.1: 77 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

3.1: 97 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

4.1: 86 percent / EDC; hydroxybenztriazole / CH₂Cl₂ / 20 °C

With sodium azide; hydrogen; ammonium chloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 10percent Pd/C; In methanol; dichloromethane; water; ethyl acetate;
DOI:10.1021/jm000481x