(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

Base Information

Chemical Name:(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine
CAS No.:624736-71-6
Molecular Formula:C₂₁H₂₉NO₃
Molecular Weight:343.466
Hs Code.:

Synonyms:(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

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Chemical Property of (6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

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Technology Process of (6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

There total 2 articles about (6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 15356-60-2
(1S,2R,5S)-(+)-menthol

: 624736-67-0
6-ethoxy-3-(p-methoxyphenyl)-6H-1,2-oxazine

: 624736-71-6
(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

: 624736-70-5
(6R)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1002/ejoc.200300234

Reference yield:

: 71426-53-4
α-bromo-(p-methoxy)acetophenonoxime

: 624736-71-6
(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / CH₂Cl₂; various solvent(s) / 216 h / 20 °C

1.2: 44 percent / DBU / CH₂Cl₂; various solvent(s) / 16 h / 20 °C

2.1: 45 percent / BF₃*OEt₂ / CH₂Cl₂ / 24 h / 20 °C

With boron trifluoride diethyl etherate; sodium carbonate; In dichloromethane;
DOI:10.1002/ejoc.200300234

Reference yield: 32.0%

: 2635-13-4
1,2-(methylenedioxy)-4-bromobenzene

: 623-49-4
ethyl cyanoformate

: 624736-71-6
(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine

: ethyl (6S)-5-(1,3-benzodioxol-5-yl)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(4-methoxyphenyl)-5,6-dihydro-4H-1,2-oxazine-4-carboxylate

Guidance literature:: 1,2-(methylenedioxy)-4-bromobenzene; With tert.-butyl lithium; In tetrahydrofuran; pentane; at -78 ℃; for 0.5h;

(6S)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(p-methoxyphenyl)-6H-1,2-oxazine; In tetrahydrofuran; pentane; at -78 ℃;

ethyl cyanoformate; In tetrahydrofuran; pentane; at -78 ℃; for 1h; Further stages.;
DOI:10.1002/ejoc.200300234