71426-53-4

Upstream product

• 2632-13-5 2-Bromo-4'-methoxyacetophenone 
• 100-06-1 1-(4-methoxyphenyl)ethanone 

Downstream Products

• 71426-70-5 [2-[(Z)-1-Methoxy-1-methyl-ethoxyimino]-2-(4-methoxy-phenyl)-ethyl]-triphenyl-phosphonium; bromide 
• 86685-98-5 3-(4-methoxyphenyl)-1,2-oxazol-5-amine 
• 624736-67-0 6-ethoxy-3-(p-methoxyphenyl)-6H-1,2-oxazine 
• 73744-32-8 (Z)-1-(4-methoxyphenyl)ethanone oxime 
• 1434602-95-5 (Z)-1-(4-methoxyphenyl)ethanone O-benzyloxime 
• 6298-96-0 1(R)-(4-methoxyphenyl)-ethylamine 
• 71426-59-0 [2-hydroxyimino-2-(4-methoxy-phenyl)-ethyl]-triphenyl-phosphonium; bromide 
• 71426-74-9 3-(4-methoxy-phenyl)-5,5,5-triphenyl-4,5-dihydro-5λ⁵-[1,2,5]oxazaphosphole 
• 624736-74-9 ethyl (6R)-5-(1,3-benzodioxol-5-yl)-6-[(1S,2R,5S)-2-isopropyl-5-methylcyclohexyloxy]-3-(4-methoxyphenyl)-5,6-dihydro-4H-1,2-oxazine-4-carboxylate 
• 624736-78-3 ethyl (6S)-5-(1,3-benzodioxol-5-yl)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-3-(4-methoxyphenyl)-5,6-dihydro-4H-1,2-oxazine-4-carboxylate 

Relevant academic research and scientific papers

Asymmetric synthesis of nonracemic primary amines via spiroborate-catalyzed reduction of pure (E)- and (Z)-O-benzyloximes: Applications toward the synthesis of calcimimetic agents

Highly enantiopure (1-aryl)- and (1-naphthyl)-1-ethylamines were synthesized by the borane-mediated reduction of single-isomeric (E)- and (Z)-O-benzyloxime ethers using the stable spiroborate ester derived from (S)-diphenyl valinol and ethylene glycol as the chiral catalyst. Primary (R)-arylethylamines were prepared by the reduction of pure (Z)-ethanone oxime ethers in up to 99% ee using 15% of catalyst. Two convenient and facile approaches to the synthesis of new and known calcimimetic analogues employing enantiopure (1-naphthalen-1-yl)ethylamine as chiral precursor are described.