(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

Base Information

Chemical Name:(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate
CAS No.:1360110-23-1
Molecular Formula:C₁₇H₂₄NO₈P
Molecular Weight:401.353
Hs Code.:

Synonyms:(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

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Chemical Property of (S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

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Technology Process of (S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

There total 2 articles about (S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3095-95-2
diethylphosphonoacetic acid

: 727683-89-8
3-hydroxy-2,2-dimethyl-3-(4-nitrophenyl)propionaldehyde

: 1360110-23-1
(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1055/s-0031-1289629

Reference yield:

: 555-16-8
4-nitrobenzaldehdye

: 1360110-23-1
(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; trifluoroacetic acid / dimethyl sulfoxide / 12 h / 20 °C

2: dmap; dicyclohexyl-carbodiimide / dichloromethane / 24 h / 0 - 20 °C

With dmap; (S)-2-(1-pyrrolidinylmethyl)pyrrolidine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; 1: Aldol reaction / 2: Michael addition;
DOI:10.1055/s-0031-1289629

Reference yield:

: 1360110-23-1
(S)-2,2-dimethyl-1-(4-nitrophenyl)-3-oxopropyl (diethoxyphosphoryl)acetate

: 1360110-27-5
diethyl [(4S,6R)-5,5-dimethyl-6-(4-nitrophenyl)-2-oxo-4-(2-oxopropyl)tetrahydro-2H-pyran-3-yl]phosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; acetic acid / benzene / Reflux

2: pyrrolidine / 20 °C

With pyrrolidine; piperidine; acetic acid; In benzene; 1: Knoevenagel condensation / 2: Michael addition;
DOI:10.1055/s-0031-1289629